Reactome | Activated calmodulin binds ADCY1,ADCY8

Activated calmodulin binds ADCY1,ADCY8

Stable Identifier

R-HSA-9617535

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
        
        Activated calmodulin binds ADCY1,ADCY8 (Homo sapiens)

General

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Calmodulin (CALM1, also known as CaM), activated by binding to Ca2+ ions, forms a complex with adenylate cyclase 1 (ADCY1, also known as AC1) (Levin and Reed 1995, Masada et al. 2012) or adenylate cyclase 8 (ADCY8, also known as AC8) (Gu and Cooper 1999, Masada et al. 2012, Herbst et al. 2013), thereby activating them.

Participants

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