CDK5R1 is a neuron-specific regulatory subunit of CDK5 that activates CDK5 kinase activity in a cyclin-type manner and CDK5R1 and CDK5 co-precipitate from rat PC12 cells and from bovine brain (Tsai et al, 1994; Lew et al, 1994; Harada et al, 2001). CDK5 activity is required for neurite outgrowth and disruption of CDK5 or CDK5R1 leads to defects in neuronal migration in mice (Nikolic et al, 1996; Xiong et al, 1997; Paglini et al, 1998). A second CDK5 regulatory protein, CDK5R2 (also known as p39) is required for CDK5-dependent neurite outgrowth in response to bFGF (Tang et al, 1995; Xiong et al, 1997).
Xiong, W, Pestell, R, Rosner, MR
Paglini, G, Pigino, G, Kunda, P, Morfini, G, Maccioni, R, Quiroga, S, Ferreira, A, Caceres, A
Lew, J, Huang, QQ, Qi, Z, Winkfein, RJ, Aebersold, R, Hunt, T, Wang, JH
Harada, T, Morooka, T, Ogawa, S, Nishida, E
Tsai, LH, Delalle, I, Caviness, VS, Chae, T, Harlow, E
Nikolic, M, Dudek, H, Kwon, YT, Ramos, YF, Tsai, LH
Tang, D, Yeung, J, Lee, KY, Matsushita, M, Matsui, H, Tomizawa, K, Hatase, O, Wang, JH
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