CDK5R1 is a neuron-specific regulatory subunit of CDK5 that activates CDK5 kinase activity in a cyclin-type manner and CDK5R1 and CDK5 co-precipitate from rat PC12 cells and from bovine brain (Tsai et al, 1994; Lew et al, 1994; Harada et al, 2001). CDK5 activity is required for neurite outgrowth and disruption of CDK5 or CDK5R1 leads to defects in neuronal migration in mice (Nikolic et al, 1996; Xiong et al, 1997; Paglini et al, 1998). A second CDK5 regulatory protein, CDK5R2 (also known as p39) is required for CDK5-dependent neurite outgrowth in response to bFGF (Tang et al, 1995; Xiong et al, 1997).
Kunda, P, Paglini, G, Morfini, G, Caceres, A, Maccioni, R, Pigino, G, Ferreira, A, Quiroga, S
Rosner, MR, Pestell, R, Xiong, W
Lew, J, Wang, JH, Aebersold, R, Huang, QQ, Hunt, T, Qi, Z, Winkfein, RJ
Harada, T, Nishida, E, Ogawa, S, Morooka, T
Chae, T, Caviness, VS, Harlow, E, Delalle, I, Tsai, LH
Kwon, YT, Dudek, H, Tsai, LH, Nikolic, M, Ramos, YF
Yeung, J, Matsushita, M, Tang, D, Matsui, H, Lee, KY, Wang, JH, Tomizawa, K, Hatase, O
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