MyrG-CDK5R1,2 bind CDK5

Stable Identifier
Homo sapiens
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CDK5R1 is a neuron-specific regulatory subunit of CDK5 that activates CDK5 kinase activity in a cyclin-type manner and CDK5R1 and CDK5 co-precipitate from rat PC12 cells and from bovine brain (Tsai et al, 1994; Lew et al, 1994; Harada et al, 2001). CDK5 activity is required for neurite outgrowth and disruption of CDK5 or CDK5R1 leads to defects in neuronal migration in mice (Nikolic et al, 1996; Xiong et al, 1997; Paglini et al, 1998). A second CDK5 regulatory protein, CDK5R2 (also known as p39) is required for CDK5-dependent neurite outgrowth in response to bFGF (Tang et al, 1995; Xiong et al, 1997).

Literature References
PubMed ID Title Journal Year
9822744 Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth

Kunda, P, Paglini, G, Morfini, G, Caceres, A, Maccioni, R, Pigino, G, Ferreira, A, Quiroga, S

J. Neurosci. 1998
9343422 Role of cyclins in neuronal differentiation of immortalized hippocampal cells

Rosner, MR, Pestell, R, Xiong, W

Mol. Cell. Biol. 1997
8090222 A brain-specific activator of cyclin-dependent kinase 5

Lew, J, Wang, JH, Aebersold, R, Huang, QQ, Hunt, T, Qi, Z, Winkfein, RJ

Nature 1994
11331872 ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1

Harada, T, Nishida, E, Ogawa, S, Morooka, T

Nat. Cell Biol. 2001
8090221 p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

Chae, T, Caviness, VS, Harlow, E, Delalle, I, Tsai, LH

Nature 1994
8846918 The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

Kwon, YT, Dudek, H, Tsai, LH, Nikolic, M, Ramos, YF

Genes Dev. 1996
7592934 An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator

Yeung, J, Matsushita, M, Tang, D, Matsui, H, Lee, KY, Wang, JH, Tomizawa, K, Hatase, O

J. Biol. Chem. 1995
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