MyrG-CDK5R1,2 bind CDK5

Stable Identifier
R-HSA-9616368
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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MyrG-CDK5R1,2 bind CDK5
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CDK5R1 is a neuron-specific regulatory subunit of CDK5 that activates CDK5 kinase activity in a cyclin-type manner and CDK5R1 and CDK5 co-precipitate from rat PC12 cells and from bovine brain (Tsai et al, 1994; Lew et al, 1994; Harada et al, 2001). CDK5 activity is required for neurite outgrowth and disruption of CDK5 or CDK5R1 leads to defects in neuronal migration in mice (Nikolic et al, 1996; Xiong et al, 1997; Paglini et al, 1998). A second CDK5 regulatory protein, CDK5R2 (also known as p39) is required for CDK5-dependent neurite outgrowth in response to bFGF (Tang et al, 1995; Xiong et al, 1997).

Literature References
PubMed ID Title Journal Year
9343422 Role of cyclins in neuronal differentiation of immortalized hippocampal cells

Xiong, W, Pestell, R, Rosner, MR

Mol. Cell. Biol. 1997
9822744 Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth

Paglini, G, Pigino, G, Kunda, P, Morfini, G, Maccioni, R, Quiroga, S, Ferreira, A, Caceres, A

J. Neurosci. 1998
8090222 A brain-specific activator of cyclin-dependent kinase 5

Lew, J, Huang, QQ, Qi, Z, Winkfein, RJ, Aebersold, R, Hunt, T, Wang, JH

Nature 1994
11331872 ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1

Harada, T, Morooka, T, Ogawa, S, Nishida, E

Nat. Cell Biol. 2001
8090221 p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

Tsai, LH, Delalle, I, Caviness, VS, Chae, T, Harlow, E

Nature 1994
8846918 The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

Nikolic, M, Dudek, H, Kwon, YT, Ramos, YF, Tsai, LH

Genes Dev. 1996
7592934 An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator

Tang, D, Yeung, J, Lee, KY, Matsushita, M, Matsui, H, Tomizawa, K, Hatase, O, Wang, JH

J. Biol. Chem. 1995
Participants
Input
Output
Participant Of
hasEvent
Inferred From
MyrG-Cdk5r1(2-307) binds Cdk5 (Rattus norvegicus)
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-08-10)