Reactome | 14-3-3 proteins bind AKT-phosphorylated FOXO4

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14-3-3 proteins bind AKT-phosphorylated FOXO4 Show undefined attributes

authored	[InstanceEdit:9624371] Orlic-Milacic, Marija, 2018-10-11
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9614567] Orlic-Milacic, Marija, 2018-07-27
dbId	9614564
displayName	14-3-3 proteins bind AKT-phosphorylated FOXO4
edited	[InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
eventOf	[Pathway:R-HSA-9614399] Regulation of localization of FOXO transcription factors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9614415] p-T32,S197,S262-FOXO4 [cytosol] [Complex:R-HSA-206751] YWHAZ dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9614553] 14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4 [LiteratureReference:9614557] 14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4 [LiteratureReference:9614543] Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor Foxo4 are important for DNA binding
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	14-3-3 proteins bind AKT-phosphorylated FOXO4
orthologousEvent	[Reaction:R-CEL-9614564] 14-3-3 proteins bind AKT-phosphorylated FOXO4 - Caenorhabditis elegans [Reaction:R-DME-9614564] 14-3-3 proteins bind AKT-phosphorylated FOXO4 - Drosophila melanogaster [Reaction:R-GGA-9614564] 14-3-3 proteins bind AKT-phosphorylated FOXO4 - Gallus gallus [Reaction:R-XTR-9614564] 14-3-3 proteins bind AKT-phosphorylated FOXO4 - Xenopus tropicalis [Reaction:R-BTA-9614564] 14-3-3 proteins bind AKT-phosphorylated FOXO4 - Bos taurus [Reaction:R-CFA-9614564] 14-3-3 proteins bind AKT-phosphorylated FOXO4 - Canis familiaris [Reaction:R-RNO-9614564] 14-3-3 proteins bind AKT-phosphorylated FOXO4 - Rattus norvegicus [Reaction:R-MMU-9614564] 14-3-3 proteins bind AKT-phosphorylated FOXO4 - Mus musculus
output	[Complex:R-HSA-9614653] p-T32,S197,S262-FOXO4:YWHAZ dimer [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Homo sapiens
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9625979] Donlon, Timothy, 2018-10-17 [InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9614564
summation	[Summation:9614652] Nuclear exclusion and cytoplasmic retention of AKT-phosphory...

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[Pathway:R-HSA-9614399] Regulation of localization of FOXO transcription factors