Reactome | AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol

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AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol Show undefined attributes

authored	[InstanceEdit:9624371] Orlic-Milacic, Marija, 2018-10-11
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9614412] Orlic-Milacic, Marija, 2018-07-26
dbId	9614414
displayName	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol
edited	[InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
eventOf	[Pathway:R-HSA-9614399] Regulation of localization of FOXO transcription factors - Homo sapiens
followingEvent	[Reaction:R-HSA-9614564] 14-3-3 proteins bind AKT-phosphorylated FOXO4 - Homo sapiens [Reaction:R-HSA-9614423] 14-3-3 proteins bind AKT-phosphorylated FOXO1 - Homo sapiens [Reaction:R-HSA-9614562] 14-3-3 proteins bind AKT-phosphorylated FOXO3 - Homo sapiens
input	[DefinedSet:R-HSA-199269] p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199277] Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor [LiteratureReference:9614553] 14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4 [LiteratureReference:199294] Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B [LiteratureReference:199313] Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol
orthologousEvent	[BlackBoxEvent:R-CEL-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Caenorhabditis elegans [BlackBoxEvent:R-DME-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Drosophila melanogaster [BlackBoxEvent:R-GGA-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Gallus gallus [BlackBoxEvent:R-XTR-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Xenopus tropicalis [BlackBoxEvent:R-DRE-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Danio rerio [BlackBoxEvent:R-SSC-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Sus scrofa [BlackBoxEvent:R-BTA-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Bos taurus [BlackBoxEvent:R-CFA-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Canis familiaris [BlackBoxEvent:R-RNO-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Rattus norvegicus [BlackBoxEvent:R-MMU-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Mus musculus
output	[DefinedSet:R-HSA-9614416] p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [cytosol]
precedingEvent	[Reaction:R-HSA-199299] AKT phosphorylates FOXO transcription factors - Homo sapiens
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9625979] Donlon, Timothy, 2018-10-17 [InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9614414
summation	[Summation:9614560] AKT-mediated phosphorylation results in exclusion of FOXO1 (...

Referrals

(hasEvent)	[Pathway:R-HSA-9614399] Regulation of localization of FOXO transcription factors
(precedingEvent)	[Reaction:R-HSA-9614564] 14-3-3 proteins bind AKT-phosphorylated FOXO4 [Reaction:R-HSA-9614423] 14-3-3 proteins bind AKT-phosphorylated FOXO1 [Reaction:R-HSA-9614562] 14-3-3 proteins bind AKT-phosphorylated FOXO3

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