EGR1 and NAB co-repressors bind EGR1 gene

Stable Identifier
R-HSA-9613202
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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EGR1 and NAB co-repressors bind EGR1 gene
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EGR1 expression is repressed by the recruitment of NAB proteins (NGFI-A binding protein) 1 and 2 through an interaction with EGR1 at its cognate promoter site, establishing a negative feedback loop (Russo et al, 1993; Russo et al, 1995; Svaren et al, 1996; Kumbrick et al, 2005; Kumbrick et al, 2010). NAB proteins interact with the EGR R1 domain through a conserved NCD1 domain (NAB conserved domain 1) and this interaction is abrogated by mutation of EGR residue I293 (Svaren et al, 1996; Russo, 1993). NCD1 is also required for multimerization of the NAB proteins (Savern et al, 1996; Svaren et al, 1998). Two other conserved regions of NAB proteins (NCD2 and CID, for CHD4-interacting domain) are required for the repression function of the proteins (Svaren et al, 1996; Srinivasan et al, 2006). In some contexts, NAB proteins have also been shown to activate EGR-mediated transcription, and EGR- and NAB-dependent transcription is required for peripheral nervous system myelination (Sevetson et al, 2000; Le et al, 2005).
Literature References
PubMed ID Title Journal Year
10734128 A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene

Sevetson, BR, Svaren, J, Milbrandt, J

J. Biol. Chem. 2000
16136673 Nab proteins are essential for peripheral nervous system myelination

Le, N, Nagarajan, R, Wang, JY, Svaren, J, LaPash, C, Araki, T, Schmidt, RE, Milbrandt, J

Nat. Neurosci. 2005
16574654 NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex

Srinivasan, R, Mager, GM, Ward, RM, Mayer, J, Svaren, J

J. Biol. Chem. 2006
8668170 NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli

Svaren, J, Sevetson, BR, Apel, ED, Zimonjic, DB, Popescu, NC, Milbrandt, J

Mol. Cell. Biol. 1996
8413279 Transcriptional activity of the zinc finger protein NGFI-A is influenced by its interaction with a cellular factor

Russo, MW, Matheny, C, Milbrandt, J

Mol. Cell. Biol. 1993
16260776 Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop

Kumbrink, J, Gerlinger, M, Johnson, JP

J. Biol. Chem. 2005
7624335 Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription

Russo, MW, Sevetson, BR, Milbrandt, J

Proc. Natl. Acad. Sci. U.S.A. 1995
9774344 Novel mutants of NAB corepressors enhance activation by Egr transactivators

Svaren, J, Sevetson, BR, Golda, T, Stanton, JJ, Swirnoff, AH, Milbrandt, J

EMBO J. 1998
20506119 EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin

Kumbrink, J, Kirsch, KH, Johnson, JP

J. Cell. Biochem. 2010
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Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-07-12)
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