EGR1 expression is repressed by the recruitment of NAB proteins (NGFI-A binding protein) 1 and 2 through an interaction with EGR1 at its cognate promoter site, establishing a negative feedback loop (Russo et al, 1993; Russo et al, 1995; Svaren et al, 1996; Kumbrick et al, 2005; Kumbrick et al, 2010). NAB proteins interact with the EGR R1 domain through a conserved NCD1 domain (NAB conserved domain 1) and this interaction is abrogated by mutation of EGR residue I293 (Svaren et al, 1996; Russo, 1993). NCD1 is also required for multimerization of the NAB proteins (Savern et al, 1996; Svaren et al, 1998). Two other conserved regions of NAB proteins (NCD2 and CID, for CHD4-interacting domain) are required for the repression function of the proteins (Svaren et al, 1996; Srinivasan et al, 2006). In some contexts, NAB proteins have also been shown to activate EGR-mediated transcription, and EGR- and NAB-dependent transcription is required for peripheral nervous system myelination (Sevetson et al, 2000; Le et al, 2005).
Milbrandt, J, Sevetson, BR, Svaren, J
Nagarajan, R, Wang, JY, Araki, T, Le, N, Milbrandt, J, Svaren, J, LaPash, C, Schmidt, RE
Mager, GM, Ward, RM, Mayer, J, Svaren, J, Srinivasan, R
Popescu, NC, Zimonjic, DB, Milbrandt, J, Apel, ED, Sevetson, BR, Svaren, J
Russo, MW, Milbrandt, J, Matheny, C
Gerlinger, M, Johnson, JP, Kumbrink, J
Russo, MW, Milbrandt, J, Sevetson, BR
Swirnoff, AH, Milbrandt, J, Sevetson, BR, Svaren, J, Stanton, JJ, Golda, T
Johnson, JP, Kumbrink, J, Kirsch, KH
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