EGR1 expression is repressed by the recruitment of NAB proteins (NGFI-A binding protein) 1 and 2 through an interaction with EGR1 at its cognate promoter site, establishing a negative feedback loop (Russo et al, 1993; Russo et al, 1995; Svaren et al, 1996; Kumbrick et al, 2005; Kumbrick et al, 2010). NAB proteins interact with the EGR R1 domain through a conserved NCD1 domain (NAB conserved domain 1) and this interaction is abrogated by mutation of EGR residue I293 (Svaren et al, 1996; Russo, 1993). NCD1 is also required for multimerization of the NAB proteins (Savern et al, 1996; Svaren et al, 1998). Two other conserved regions of NAB proteins (NCD2 and CID, for CHD4-interacting domain) are required for the repression function of the proteins (Svaren et al, 1996; Srinivasan et al, 2006). In some contexts, NAB proteins have also been shown to activate EGR-mediated transcription, and EGR- and NAB-dependent transcription is required for peripheral nervous system myelination (Sevetson et al, 2000; Le et al, 2005).
Le, N, Nagarajan, R, Wang, JY, Svaren, J, LaPash, C, Araki, T, Schmidt, RE, Milbrandt, J
Sevetson, BR, Svaren, J, Milbrandt, J
Srinivasan, R, Mager, GM, Ward, RM, Mayer, J, Svaren, J
Svaren, J, Sevetson, BR, Apel, ED, Zimonjic, DB, Popescu, NC, Milbrandt, J
Russo, MW, Matheny, C, Milbrandt, J
Kumbrink, J, Gerlinger, M, Johnson, JP
Russo, MW, Sevetson, BR, Milbrandt, J
Svaren, J, Sevetson, BR, Golda, T, Stanton, JJ, Swirnoff, AH, Milbrandt, J
Kumbrink, J, Kirsch, KH, Johnson, JP
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