Reactome | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Schema > Pathway > Entries

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Show undefined attributes

authored	[InstanceEdit:9609524] May, Bruce, 2018-05-28
created	[InstanceEdit:9609525] May, Bruce, 2018-05-29
dbId	9609523
displayName	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
doi	10.3180/R-HSA-9609523.1
edited	[InstanceEdit:9609524] May, Bruce, 2018-05-28
eventOf	[TopLevelPathway:R-HSA-9609507] Protein localization - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18899] protein insertion into ER membrane
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9609921] SGTA binds Tail-anchored protein - Homo sapiens [Reaction:R-HSA-9610442] Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP - Homo sapiens [BlackBoxEvent:R-HSA-9609860] Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP - Homo sapiens [Reaction:R-HSA-9609899] Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane - Homo sapiens [Reaction:R-HSA-9609917] Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane - Homo sapiens [Reaction:R-HSA-9617595] SGTA binds mislocalized membrane protein - Homo sapiens [Reaction:R-HSA-9617596] BAG6:GET4:UBL4A binds mislocalized membrane protein:SGTA and ASNA1:ATP - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9609910] Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion [LiteratureReference:9609881] Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins [LiteratureReference:9610443] Mechanistic basis for a molecular triage reaction [LiteratureReference:9614363] Targeting pathways of C-tail-anchored proteins [LiteratureReference:9614091] Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6 [LiteratureReference:9614430] SGTA antagonizes BAG6-mediated protein triage [LiteratureReference:9610447] SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation [LiteratureReference:9613963] SGTA regulates the cytosolic quality control of hydrophobic substrates [LiteratureReference:9613969] A biochemical analysis of the constraints of tail-anchored protein biogenesis [LiteratureReference:9613947] Human SGT interacts with Bag-6/Bat-3/Scythe and cells with reduced levels of either protein display persistence of few misaligned chromosomes and mitotic arrest [LiteratureReference:9610440] The association of BAG6 with SGTA and tail-anchored proteins [LiteratureReference:9613965] Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface [LiteratureReference:9610457] A ribosome-associating factor chaperones tail-anchored membrane proteins [LiteratureReference:9613944] WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane [LiteratureReference:9609907] Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing [LiteratureReference:9613995] WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane [LiteratureReference:9617642] Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation [LiteratureReference:9614429] A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation [LiteratureReference:9617644] On the road to nowhere: cross-talk between post-translational protein targeting and cytosolic quality control [LiteratureReference:9617645] Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control [LiteratureReference:9610459] Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain [LiteratureReference:9614098] Structural and functional insights into the E3 ligase, RNF126 [LiteratureReference:9628376] Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis [LiteratureReference:9628384] The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase [LiteratureReference:9628393] The SND proteins constitute an alternative targeting route to the endoplasmic reticulum
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
orthologousEvent	[Pathway:R-MMU-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Mus musculus [Pathway:R-RNO-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Rattus norvegicus [Pathway:R-CFA-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Canis familiaris [Pathway:R-BTA-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Bos taurus [Pathway:R-SSC-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Sus scrofa [Pathway:R-DRE-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Danio rerio [Pathway:R-XTR-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Xenopus tropicalis [Pathway:R-GGA-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Gallus gallus [Pathway:R-DME-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Drosophila melanogaster [Pathway:R-CEL-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Caenorhabditis elegans [Pathway:R-DDI-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Dictyostelium discoideum [Pathway:R-SPO-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Schizosaccharomyces pombe [Pathway:R-SCE-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Saccharomyces cerevisiae [Pathway:R-PFA-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Plasmodium falciparum
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9628231] DeLaurentiis, Evelina, 2018-11-07 [InstanceEdit:9628224] Farkas, �kos, 2018-11-07 [InstanceEdit:9628222] Schwappach, Blanche, 2018-11-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9609523
summation	[Summation:9609914] Tail-anchored (TA) proteins have a hydrophobic transmembrane...

Referrals

(hasEvent)

[TopLevelPathway:R-HSA-9609507] Protein localization

Cite Us!