Reactome | Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane

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Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane Show undefined attributes

authored	[InstanceEdit:9609862] May, Bruce, 2018-06-03
category	dissociation
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9609858] May, Bruce, 2018-06-03
dbId	9609917
deleted	[Deleted:9629903] Deletion of instance: 5250579
displayName	Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane
edited	[InstanceEdit:9609862] May, Bruce, 2018-06-03
eventOf	[Pathway:R-HSA-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane - Homo sapiens
inferredFrom	[Reaction:R-SCE-9628640] SBH1:GET3:ADP:GET1:GET2 dissociates yielding SBH1 in the endoplasmic reticulum membrane - Saccharomyces cerevisiae
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9609912] Tail-anchored protein:ASNA1:ADP:WRB:CAMLG [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5250572] Identification of a targeting factor for posttranslational membrane protein insertion into the ER [LiteratureReference:5250588] Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins [LiteratureReference:5250553] Asna1/TRC40-mediated membrane insertion of tail-anchored proteins [LiteratureReference:9613959] Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells [LiteratureReference:9613944] WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane [LiteratureReference:9613973] Tail-anchored Protein Insertion in Mammals: FUNCTION AND RECIPROCAL INTERACTIONS OF THE TWO SUBUNITS OF THE TRC40 RECEPTOR [LiteratureReference:9613989] Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane [LiteratureReference:9609907] Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9609895] ASNA1:ATP dimer [cytosol] [DefinedSet:R-HSA-9609893] Tail-anchored proteins [endoplasmic reticulum membrane] [Complex:R-HSA-9609864] WRB:CAMLG [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-9609899] Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9628231] DeLaurentiis, Evelina, 2018-11-07 [InstanceEdit:9628224] Farkas, �kos, 2018-11-07 [InstanceEdit:9628222] Schwappach, Blanche, 2018-11-07 [InstanceEdit:9629086] DeLaurentiis, Evelina, 2018-11-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9609917
summation	[Summation:9614005] A tail-anchored protein bound to ASNA1 (TRC40) (Stefanovic a...

Referrals

(replacementInstances)	[Deleted:9629903] Deletion of instance: 5250579
(hasEvent)	[Pathway:R-HSA-9609523] Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
(inferredTo)	[Reaction:R-SCE-9628640] SBH1:GET3:ADP:GET1:GET2 dissociates yielding SBH1 in the endoplasmic reticulum membrane

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