Reactome | PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated

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PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated Show undefined attributes

authored	[InstanceEdit:9606896] May, Bruce, 2018-04-22
category	uncertain
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9606882] May, Bruce, 2018-04-26
dbId	9606884
deleted	[Deleted:9613688] Deletion of instance: 983704
displayName	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated
edited	[InstanceEdit:9606896] May, Bruce, 2018-04-22
eventOf	[Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - Homo sapiens
followingEvent	[Reaction:R-HSA-9606894] p-DAPP1 (p-BAM32) binds PLCG2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-197950] DAPP1 [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9606966] Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase [LiteratureReference:9606950] Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains [LiteratureReference:9606973] DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides [LiteratureReference:1168970] A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated
orthologousEvent	[BlackBoxEvent:R-GGA-9606884] PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated - Gallus gallus [BlackBoxEvent:R-DDI-9606884] PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated - Dictyostelium discoideum [BlackBoxEvent:R-XTR-9606884] PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated - Xenopus tropicalis [BlackBoxEvent:R-DRE-9606884] PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated - Danio rerio [BlackBoxEvent:R-SSC-9606884] PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated - Sus scrofa [BlackBoxEvent:R-BTA-9606884] PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated - Bos taurus [BlackBoxEvent:R-CFA-9606884] PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated - Canis familiaris [BlackBoxEvent:R-RNO-9606884] PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated - Rattus norvegicus [BlackBoxEvent:R-MMU-9606884] PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1168366] p-Y139-DAPP1:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Homo sapiens [Reaction:R-HSA-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Homo sapiens
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9613695] Wienands, J, 2018-07-18
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9606884
summation	[Summation:9607053] DAPP1 (BAM32) is recruited to the plasma membrane by the bin...

Referrals

(replacementInstances)	[Deleted:9613688] Deletion of instance: 983704
(hasEvent)	[Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
(precedingEvent)	[Reaction:R-HSA-9606894] p-DAPP1 (p-BAM32) binds PLCG2