Reactome | PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated

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PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10318266
displayName	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated
eventOf	[Pathway:R-CFA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9606894] p-DAPP1 (p-BAM32) binds PLCG2 - Canis familiaris
inferredFrom	[BlackBoxEvent:R-HSA-9606884] PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-CFA-197950] DAPP1 [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-1168366] p-Y139-DAPP1:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-CFA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Canis familiaris [Reaction:R-CFA-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Canis familiaris
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-9606884
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
(precedingEvent)	[Reaction:R-CFA-9606894] p-DAPP1 (p-BAM32) binds PLCG2
(inferredTo)	[BlackBoxEvent:R-HSA-9606884] PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated

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