Reactome | PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated

PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated

Stable Identifier

R-HSA-9606884

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane

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PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated

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DAPP1 (BAM32) is recruited to the plasma membrane by the binding of its PH domain to phosphoinositol 3,4,5-trisphosphate (PIP3) (Dowler et al. 1999, Marshall et al. 2000, Ferguson et al. 2000). DAPP1 also binds phosphatidylinositol 3,4-bisphosphate (Dowler et al. 1999, Ferguson et al. 2000) and therefore remains bound at the plasma membrane after PIP3 has been dephosphorylated by phosphatases. At the plasma membrane DAPP1 is phosphorylated by a Src family kinase, likely LYN in B cells (Dowler et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10770799	A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase Marshall, AJ, Niiro, H, Lerner, CG, Yun, TJ, Thomas, S, Disteche, CM, Clark, EA	J Exp Med	2000
10432293	DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides Dowler, S, Currie, RA, Downes, CP, Alessi, DR	Biochem. J.	1999
10983984	Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains Ferguson, KM, Kavran, JM, Sankaran, VG, Fournier, E, Isakoff, SJ, Skolnik, EY, Lemmon, MA	Mol. Cell	2000
10880360	Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase Dowler, S, Montalvo, L, Cantrell, D, Morrice, N, Alessi, DR	Biochem. J.	2000