Reactome | GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated

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GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated Show undefined attributes

authored	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9606626] Varusai, Thawfeek, 2018-04-24
dbId	9606622
diseaseReaction	[Reaction:R-HSA-9698003] FLT3 mutants phosphorylate GAB2 - Homo sapiens
displayName	GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated
edited	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
eventOf	[Pathway:R-HSA-9607240] FLT3 Signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9606784] Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 - Homo sapiens [Reaction:R-HSA-9607224] Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9606621] Gab2 in Active Flt3:Grb2:Gab2 is phosphorylated - Mus musculus
input	[Complex:R-HSA-9606619] Active FLT3:GRB2:GAB2 [plasma membrane] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:6786770] Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase [LiteratureReference:9604764] A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival [LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated
output	[Complex:R-HSA-9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-9606624] Active FLT3:GRB2 binds GAB2 - Homo sapiens
releaseDate	2019-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9645124] Traer, Elie, 2019-05-03 [InstanceEdit:9646275] Joshi, Sunil, 2019-05-21
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9606622
summation	[Summation:9606630] Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a me...

Referrals

(hasEvent)	[Pathway:R-HSA-9607240] FLT3 Signaling
(normalReaction)	[Reaction:R-HSA-9698003] FLT3 mutants phosphorylate GAB2
(precedingEvent)	[BlackBoxEvent:R-HSA-9606784] Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 [Reaction:R-HSA-9607224] Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1
(inferredTo)	[BlackBoxEvent:R-MMU-9606621] Gab2 in Active Flt3:Grb2:Gab2 is phosphorylated

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