Reactome | Active FLT3:GRB2:p-Y-GAB2 [plasma membrane]

Schema > Complex > Entries

Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9606788] Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] - Homo sapiens
consumedByEvent	[BlackBoxEvent:R-HSA-9606784] Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 - Homo sapiens [Reaction:R-HSA-9607224] Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 - Homo sapiens
created	[InstanceEdit:9606626] Varusai, Thawfeek, 2018-04-24
dbId	9606627
displayName	Active FLT3:GRB2:p-Y-GAB2 [plasma membrane]
hasComponent	[Complex:R-HSA-9604756] Active FLT3: GRB2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-912529] p-Y-GAB2 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] - Mus musculus [Complex:R-RNO-9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] - Canis familiaris [Complex:R-BTA-9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] - Bos taurus [Complex:R-SSC-9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] - Sus scrofa [Complex:R-DRE-9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] - Danio rerio [Complex:R-XTR-9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] - Gallus gallus [Complex:R-DME-9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] - Drosophila melanogaster
isChimeric	false
maxDepth	5
modified	[InstanceEdit:9634820] Varusai, Thawfeek, 2019-01-16
name	Active FLT3:GRB2:p-Y-GAB2
producedByEvent	[BlackBoxEvent:R-HSA-9606622] GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9606627
updateTrackers	[UpdateTracker:9900334] Update Tracker - [Complex:9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] - v68:[modifyName, updateContainedComponent] [UpdateTracker:9899734] Update Tracker - [Complex:9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] - v67:[removeCompartment, updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9900334] Update Tracker - [Complex:9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] - v68:[modifyName, updateContainedComponent] [UpdateTracker:9899734] Update Tracker - [Complex:9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] - v67:[removeCompartment, updateContainedComponent]
(normalEntity)	[EntityFunctionalStatus:9698188] gain_of_function of p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9606788] Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] [Complex:R-HSA-9607223] Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol]
(input)	[BlackBoxEvent:R-HSA-9606784] Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 [Reaction:R-HSA-9607224] Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1
(output)	[BlackBoxEvent:R-HSA-9606622] GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated

© 2026 Reactome

Cite Us!