p-SYK and LYN phosphorylate BTK

Stable Identifier
Reaction [uncertain]
Homo sapiens
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LYN and activated (phosphorylated) SYK phosphorylate BTK (Baba et al. 2001, Lin et al. 2009, also inferred from chicken homologs and mouse homologs) after BTK is recruited to the plasma membrane by phosphorylated BLNK (Baba et al. 2001) and phosphoinositol 3,4,5-trisphosphate (PIP3) (Salim et al. 1996). Phosphorylation of tyrosine-551 occurs within 30 seconds of B cell receptor activation and returns to low phosphorylation after 30 minutes (Nisitani et al. 1999).

Literature References
PubMed ID Title Journal Year
10051622 In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies

Witte, ON, Kato, RM, Wahl, MI, Rawlings, DJ, Nisitani, S

Proc. Natl. Acad. Sci. U.S.A. 1999
19206206 Activation loop phosphorylation modulates Bruton's tyrosine kinase (Btk) kinase domain activity

Czerwinski, R, Kelleher, K, Stahl, M, Aulabaugh, A, Lin, L, Kriz, R, Siegel, MM, Wu, P

Biochemistry 2009
8947047 Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase

Salim, K, Smith, CI, Margolis, RL, Querfurth, E, Waterfield, MD, Gout, I, Scaife, R, Gigg, R, Zvelebil, MJ, Bottomley, MJ, Panayotou, G, Driscoll, PC

EMBO J. 1996
11226282 BLNK mediates Syk-dependent Btk activation

Kishimoto, T, Tsukada, S, Baba, Y, Hashimoto, S, Matsushita, M, Watanabe, D, Kurosaki, T

Proc Natl Acad Sci U S A 2001
Catalyst Activity

protein tyrosine kinase activity of LYN, p-SYK [plasma membrane]

Inferred From
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