Reactome | FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX

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FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX Show undefined attributes

authored	[InstanceEdit:9605616] Jassal, Bijay, 2018-04-16
catalystActivity	[CatalystActivity:9605673] alpha-(1->3)-fucosyltransferase activity of FUT3,5,6,7 [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:9605659] Jassal, Bijay, 2018-04-16
dbId	9605682
displayName	FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX
edited	[InstanceEdit:9605616] Jassal, Bijay, 2018-04-16
eventOf	[Pathway:R-HSA-9037629] Lewis blood group biosynthesis - Homo sapiens
input	[SimpleEntity:R-ALL-205683] GDP-Fuc [Golgi lumen] [SimpleEntity:R-ALL-9605685] Type 2 MSGG [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9605389] A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase [LiteratureReference:9605601] Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities [LiteratureReference:9605671] The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand [LiteratureReference:9605667] Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX
orthologousEvent	[Reaction:R-BTA-9605682] FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX - Bos taurus [Reaction:R-DDI-9605682] FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX - Dictyostelium discoideum [Reaction:R-CEL-9605682] FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX - Caenorhabditis elegans [Reaction:R-DME-9605682] FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX - Drosophila melanogaster [Reaction:R-GGA-9605682] FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX - Gallus gallus [Reaction:R-XTR-9605682] FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX - Xenopus tropicalis [Reaction:R-DRE-9605682] FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX - Danio rerio [Reaction:R-SSC-9605682] FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX - Sus scrofa [Reaction:R-CFA-9605682] FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX - Canis familiaris [Reaction:R-RNO-9605682] FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX - Rattus norvegicus [Reaction:R-MMU-9605682] FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX - Mus musculus
output	[SimpleEntity:R-ALL-205689] GDP [Golgi lumen] [SimpleEntity:R-ALL-9605661] sLeX [Golgi lumen]
precedingEvent	[Reaction:R-HSA-9605600] ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9632249] Matsui, Taei, 2018-12-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9605682
summation	[Summation:9605687] Alpha-(1,3)-fucosyltransferases 3, 5, 6 and 7 (FUT3,5,6,7 re...

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(hasEvent)

[Pathway:R-HSA-9037629] Lewis blood group biosynthesis

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