Reactome | FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX

FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX

Stable Identifier

R-HSA-9605682

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Alpha-(1,3)-fucosyltransferases 3, 5, 6 and 7 (FUT3,5,6,7 respectively) mediate the transfer of fucose (Fuc) to glycan structures such as Type 2 monosialylgalactosylgloboside (Type 2 MSGG) to form the sialyl-Lewis X antigen (sLeX) (Kukowska-Latallo et al. 1990, Weston et al. 1992, Koszdin & Bowen 1992, Natsuka et al. 1994). The adhesion of sialyl-Lewis antigens to E-selectin on endothelial cell surfaces is a key step in the development of metastasis. Down-regulation of these FUTs may be a useful therapeutic approach in some cancers (Padro et al. 2011, Trinchera et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
1977660	A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase Larsen, RD, Lowe, JB, Kukowska-Latallo, JF, Nair, RP	Genes Dev.	1990
1520296	The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand Koszdin, KL, Bowen, BR	Biochem. Biophys. Res. Commun.	1992
1740457	Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities Larsen, RD, Weston, BW, Lowe, JB, Nair, RP	J. Biol. Chem.	1992
8207002	Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant Kannagi, R, Zenita, K, Gersten, KM, Lowe, JB, Natsuka, S	J. Biol. Chem.	1994