FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX

Stable Identifier
R-HSA-9605682
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Alpha-(1,3)-fucosyltransferases 3, 5, 6 and 7 (FUT3,5,6,7 respectively) mediate the transfer of fucose (Fuc) to glycan structures such as Type 2 monosialylgalactosylgloboside (Type 2 MSGG) to form the sialyl-Lewis X antigen (sLeX) (Kukowska-Latallo et al. 1990, Weston et al. 1992, Koszdin & Bowen 1992, Natsuka et al. 1994). The adhesion of sialyl-Lewis antigens to E-selectin on endothelial cell surfaces is a key step in the development of metastasis. Down-regulation of these FUTs may be a useful therapeutic approach in some cancers (Padro et al. 2011, Trinchera et al. 2011).

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Participant Of
Catalyst Activity
Catalyst Activity
Title
alpha-(1->3)-fucosyltransferase activity of FUT3,5,6,7 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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