NOTCH4 gene transcription is inhibited by RUNX1

Stable Identifier
R-HSA-9604719
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NOTCH4 gene transcription is inhibited by RUNX1
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RUNX1 binding to intron 29 of the NOTCH4 gene represses NOTCH4 transcription. RUNX1-mediated inhibition of NOTCH4 expression contributes to differentiation of human pluripotent stem cells into megakaryocytes (Li et al. 2018).

Literature References
PubMed ID Title Journal Year
29101237 Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation

Gao, Y, Chen, L, Li, Y, Liu, PP, Jin, C, Qin, L, Sun, S, Cheng, L, Bai, H, Wang, QF

Blood 2018
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of gene expression (0010629)
This event is regulated
Negatively by
Regulator
RUNX1:NOTCH4 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-05)
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