NOTCH4 gene transcription is inhibited by RUNX1

Stable Identifier
R-HSA-9604719
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NOTCH4 gene transcription is inhibited by RUNX1
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RUNX1 binding to intron 29 of the NOTCH4 gene represses NOTCH4 transcription. RUNX1-mediated inhibition of NOTCH4 expression contributes to differentiation of human pluripotent stem cells into megakaryocytes (Li et al. 2018).
Literature References
PubMed ID Title Journal Year
29101237 Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation

Gao, Y, Chen, L, Li, Y, Liu, PP, Jin, C, Qin, L, Sun, S, Cheng, L, Bai, H, Wang, QF

Blood 2018
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Output
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as an event of
Event Information
Go Biological Process
negative regulation of gene expression (0010629)
This event is regulated
Negatively by
Regulator
RUNX1:NOTCH4 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-05)
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