NOTCH4 gene transcription is inhibited by RUNX1

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R-HSA-9604719
Type
Reaction [omitted]
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Homo sapiens
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RUNX1 binding to intron 29 of the NOTCH4 gene represses NOTCH4 transcription. RUNX1-mediated inhibition of NOTCH4 expression contributes to differentiation of human pluripotent stem cells into megakaryocytes (Li et al. 2018).

Literature References
PubMed ID Title Journal Year
29101237 Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation

Li, Y, Jin, C, Bai, H, Gao, Y, Sun, S, Chen, L, Qin, L, Liu, PP, Cheng, L, Wang, QF

Blood 2018
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