Reactome | ADAM10 cleaves NOTCH4

Schema > BlackBoxEvent > Entries

ADAM10 cleaves NOTCH4 Show undefined attributes

authored	[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03 [InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
catalystActivity	[CatalystActivity:157208] metallopeptidase activity of ADAM10:Zn2+ [plasma membrane]
category	uncertain
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9604267] Orlic-Milacic, Marija, 2018-04-02
dbId	9604264
displayName	ADAM10 cleaves NOTCH4
edited	[InstanceEdit:9608067] Orlic-Milacic, Marija, 2018-05-09
eventOf	[Pathway:R-HSA-9013700] NOTCH4 Activation and Transmission of Signal to the Nucleus - Homo sapiens
followingEvent	[Reaction:R-HSA-9604294] Gamma-secretase cleaves NOTCH4 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:937686] Notch receptor processing, ligand-dependent
inferredFrom	[BlackBoxEvent:R-MMU-9604278] Adam10 cleaves Notch4 - Mus musculus
input	[DefinedSet:R-HSA-9604269] DLL4:NOTCH4,JAG1:NOTCH4 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ADAM10 cleaves NOTCH4
output	[EntityWithAccessionedSequence:R-HSA-157641] NEXT4 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2168987] DLL4 binds NOTCH4 - Homo sapiens [Reaction:R-HSA-9604247] JAG1 binds NOTCH4 - Homo sapiens
releaseDate	2005-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165114] Joutel, A, 2004-12-15 [InstanceEdit:9608066] Haw, Robin, 2018-05-01
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9604264
summation	[Summation:9604271] Based on sequence similarity with other NOTCH family members...

Referrals

(hasEvent)	[Pathway:R-HSA-9013700] NOTCH4 Activation and Transmission of Signal to the Nucleus
(precedingEvent)	[Reaction:R-HSA-9604294] Gamma-secretase cleaves NOTCH4
(inferredTo)	[BlackBoxEvent:R-MMU-9604278] Adam10 cleaves Notch4

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