Based on sequence similarity with other NOTCH family members...
| created | [InstanceEdit:9604267] Orlic-Milacic, Marija, 2018-04-02 |
| dbId | 9604271 |
| displayName | Based on sequence similarity with other NOTCH family members... |
| literatureReference | |
| schemaClass | Summation |
| text | Based on sequence similarity with other NOTCH family members and the requirement for knockout of both Notch1 and Notch4 in endothelial cells to recapitulate vasculature defects seen upon endothelial cell-specific Adam10 knockout, it is plausible that ADAM10 cleaves ligand-activated NOTCH4, releasing the membrane-bound NEXT4 fragment (Alabi et al. 2016). |
Referrals
| (summation) |
© 2026 Reactome
