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Reaction
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Entries
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
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authored
[InstanceEdit:847735] Shamovsky, V, 2010-06-01
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:937077] Shamovsky, V, 2010-08-25
dbId
937079
diseaseReaction
[FailedReaction:R-HSA-5602383] Defective MyD88 does not oligomerize within the activated TLR2/4 complex - Homo sapiens
displayName
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
edited
[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
eventOf
[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
followingEvent
[Reaction:R-HSA-166082] IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex - Homo sapiens
input
4 ×
[EntityWithAccessionedSequence:R-HSA-166059] MYD88 [cytosol]
[Complex:R-HSA-166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:937049] Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
[LiteratureReference:936987] An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4
[LiteratureReference:2428864] Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
MyD88 oligomerization within the complex of activated TLR:MAL:MyD88
output
[Complex:R-HSA-937033] oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane]
precedingEvent
[Reaction:R-HSA-166072] MyD88 forms a complex with TIRAP:activated TLR2/4 - Homo sapiens
relatedSpecies
[Species:180800] Neisseria meningitidis serogroup B
[Species:181384] Chlamydia trachomatis
releaseDate
2010-12-14
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1095192] Gillespie, ME, 2010-11-30
[InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-937079
summation
[Summation:937062] Structural analysis of MyD88:IRAK4 and MyD88:IRAK4:IRAK2 sug...
updateTrackers
[UpdateTracker:9788407] Update Tracker - [Reaction:937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 - v42:[addLiteratureReference, modifyText]
[UpdateTracker:9788162] Update Tracker - [Reaction:937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 - v43:[modifyText]
[UpdateTracker:9789566] Update Tracker - [Reaction:937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 - v37:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9788407] Update Tracker - [Reaction:937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 - v42:[addLiteratureReference, modifyText]
[UpdateTracker:9788162] Update Tracker - [Reaction:937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 - v43:[modifyText]
[UpdateTracker:9789566] Update Tracker - [Reaction:937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 - v37:[modifyText]
(normalReaction)
[FailedReaction:R-HSA-5602383] Defective MyD88 does not oligomerize within the activated TLR2/4 complex
(hasEvent)
[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane
(precedingEvent)
[Reaction:R-HSA-166082] IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
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