Reactome | MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane]

Schema > Complex > Entries

MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 - Homo sapiens
created	[InstanceEdit:166061] de Bono, B, 2005-08-16 15:14:18
dbId	166062
displayName	MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane]
hasComponent	[Complex:R-HSA-2201325] activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] [Complex:R-HSA-937078] MYD88 homodimer [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
literatureReference	[LiteratureReference:2428859] Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88 [LiteratureReference:2428798] Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
maxDepth	8
modified	[InstanceEdit:9615894] Shamovsky, Veronica, 2018-08-09
name	MyD88:TIRAP:BTK:activated TLR2/4 MyD88:MAL:BTK:activated TLR2/4
producedByEvent	[Reaction:R-HSA-166072] MyD88 forms a complex with TIRAP:activated TLR2/4 - Homo sapiens
relatedSpecies	[Species:181384] Chlamydia trachomatis [Species:180800] Neisseria meningitidis serogroup B
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-166062
updateTrackers	[UpdateTracker:9866683] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v25:[modifyName, updateContainedComponent] [UpdateTracker:9873175] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent] [UpdateTracker:9868652] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v32:[updateContainedComponent] [UpdateTracker:9892865] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v54:[updateContainedComponent] [UpdateTracker:9871047] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v39:[updateContainedComponent] [UpdateTracker:9889379] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v49:[modifyName, updateContainedComponent] [UpdateTracker:9896101] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v60:[removeSpecies, updateContainedComponent] [UpdateTracker:9872809] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v41:[add_removeHasComponent, modifyName] [UpdateTracker:9863797] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v20:[updateContainedComponent] [UpdateTracker:9868573] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v31:[updateContainedComponent] [UpdateTracker:9899912] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v67:[updateContainedComponent] [UpdateTracker:9902023] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v76:[updateContainedComponent] [UpdateTracker:9895076] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v59:[updateContainedComponent] [UpdateTracker:9899497] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v66:[addName, updateContainedComponent] [UpdateTracker:9873708] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v43:[updateContainedComponent] [UpdateTracker:9892011] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v52:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9866683] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v25:[modifyName, updateContainedComponent] [UpdateTracker:9873175] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent] [UpdateTracker:9868652] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v32:[updateContainedComponent] [UpdateTracker:9892865] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v54:[updateContainedComponent] [UpdateTracker:9871047] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v39:[updateContainedComponent] [UpdateTracker:9889379] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v49:[modifyName, updateContainedComponent] [UpdateTracker:9896101] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v60:[removeSpecies, updateContainedComponent] [UpdateTracker:9872809] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v41:[add_removeHasComponent, modifyName] [UpdateTracker:9863797] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v20:[updateContainedComponent] [UpdateTracker:9868573] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v31:[updateContainedComponent] [UpdateTracker:9899912] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v67:[updateContainedComponent] [UpdateTracker:9902023] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v76:[updateContainedComponent] [UpdateTracker:9895076] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v59:[updateContainedComponent] [UpdateTracker:9899497] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v66:[addName, updateContainedComponent] [UpdateTracker:9873708] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v43:[updateContainedComponent] [UpdateTracker:9892011] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v52:[updateContainedComponent]
(normalEntity)	[EntityFunctionalStatus:9658483] loss_of_function of MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane]
(output)	[Reaction:R-HSA-166072] MyD88 forms a complex with TIRAP:activated TLR2/4
(input)	[Reaction:R-HSA-937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88

© 2026 Reactome

Cite Us!