Reactome | ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+

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ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ Show undefined attributes

catalystActivity	[CatalystActivity:10135584] P-type sodium:potassium-exchanging transporter activity of ATP1A:ATP1B:FXYD [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10098795] Wright, Adam, 2024-03-07
dbId	10135588
displayName	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+
eventOf	[Pathway:R-CFA-5578775] Ion homeostasis - Canis familiaris [Pathway:R-CFA-936837] Ion transport by P-type ATPases - Canis familiaris
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] 2 × [SimpleEntity:R-ALL-74126] K+ [extracellular region] 3 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
isInDisease	false
isInferred	true
name	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ The Na+/K+-transporting ATPase trimer exchanges sodium for potassium
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] 2 × [SimpleEntity:R-ALL-29804] K+ [cytosol] 3 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region] [SimpleEntity:R-ALL-29372] Pi [cytosol]
regulatedBy	[NegativeRegulation:10135589] Negative regulation by 'ATP1A:ATP1B:FXYD:cardiac glycosides [plasma membrane]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-936897
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5578775] Ion homeostasis [Pathway:R-CFA-936837] Ion transport by P-type ATPases
(inferredTo)	[Reaction:R-HSA-936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+