Reactome | SMG6 hydrolyzes mRNA with premature termination codon

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SMG6 hydrolyzes mRNA with premature termination codon Show undefined attributes

authored	[InstanceEdit:927774] May, B, 2010-08-06
catalystActivity	[CatalystActivity:927876] RNA endonuclease activity of Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:927892] May, B, 2010-08-10
dbId	927836
displayName	SMG6 hydrolyzes mRNA with premature termination codon
edited	[InstanceEdit:927774] May, B, 2010-08-06
eventOf	[Pathway:R-HSA-975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex - Homo sapiens
input	[Complex:R-HSA-927854] Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:927887] SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells [LiteratureReference:927882] Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex [LiteratureReference:927772] SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	SMG6 hydrolyzes mRNA with premature termination codon
orthologousEvent	[BlackBoxEvent:R-SCE-927836] SMG6 hydrolyzes mRNA with premature termination codon - Saccharomyces cerevisiae [BlackBoxEvent:R-SPO-927836] SMG6 hydrolyzes mRNA with premature termination codon - Schizosaccharomyces pombe [BlackBoxEvent:R-CEL-927836] SMG6 hydrolyzes mRNA with premature termination codon - Caenorhabditis elegans [BlackBoxEvent:R-DME-927836] SMG6 hydrolyzes mRNA with premature termination codon - Drosophila melanogaster [BlackBoxEvent:R-GGA-927836] SMG6 hydrolyzes mRNA with premature termination codon - Gallus gallus [BlackBoxEvent:R-XTR-927836] SMG6 hydrolyzes mRNA with premature termination codon - Xenopus tropicalis [BlackBoxEvent:R-DRE-927836] SMG6 hydrolyzes mRNA with premature termination codon - Danio rerio [BlackBoxEvent:R-SSC-927836] SMG6 hydrolyzes mRNA with premature termination codon - Sus scrofa [BlackBoxEvent:R-BTA-927836] SMG6 hydrolyzes mRNA with premature termination codon - Bos taurus [BlackBoxEvent:R-CFA-927836] SMG6 hydrolyzes mRNA with premature termination codon - Canis familiaris [BlackBoxEvent:R-RNO-927836] SMG6 hydrolyzes mRNA with premature termination codon - Rattus norvegicus [BlackBoxEvent:R-MMU-927836] SMG6 hydrolyzes mRNA with premature termination codon - Mus musculus
output	[Complex:R-HSA-927845] mRNA Cleaved by SMG6 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-927813] p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1296158] Neu-Yilik, G, 2011-05-19
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-927836
summation	[Summation:927884] SMG6 is an endoribonuclease which cleaves the mRNA bound by ...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
(hasEvent)	[Pathway:R-HSA-975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)