SMG6 hydrolyzes mRNA with premature termination codon

Stable Identifier
R-HSA-927836
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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SMG6 is an endoribonuclease which cleaves the mRNA bound by UPF1 near the premature termination codon (Glavan et al. 2006, Eberle et al. 2009).

Literature References
PubMed ID Title Journal Year
17053788 Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex

Conti, E, Behm-Ansmant, I, Glavan, F, Izaurralde, E

EMBO J 2006
18974281 SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

Saulière, J, Fauser, M, Huntzinger, E, Izaurralde, E, Kashima, I

RNA 2008
19060897 SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

Jensen, TH, Eberle, AB, Lykke-Andersen, S, Muhlemann, O

Nat Struct Mol Biol 2009
Participants
Participates
Catalyst Activity

endoribonuclease activity of Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]

Orthologous Events
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