Reactome | SMG6 hydrolyzes mRNA with premature termination codon

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SMG6 hydrolyzes mRNA with premature termination codon Show undefined attributes

catalystActivity	[CatalystActivity:10858350] RNA endonuclease activity of Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10858352
displayName	SMG6 hydrolyzes mRNA with premature termination codon
eventOf	[Pathway:R-DME-975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-927836] SMG6 hydrolyzes mRNA with premature termination codon - Homo sapiens
input	[Complex:R-DME-927854] Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SMG6 hydrolyzes mRNA with premature termination codon
output	[Complex:R-DME-927845] mRNA Cleaved by SMG6 [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:56210] Drosophila melanogaster
stId	R-DME-927836
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
(inferredTo)	[BlackBoxEvent:R-HSA-927836] SMG6 hydrolyzes mRNA with premature termination codon

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