Reactome | UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex

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UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex Show undefined attributes

authored	[InstanceEdit:927774] May, B, 2010-08-06
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:927892] May, B, 2010-08-10
dbId	927832
displayName	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex
edited	[InstanceEdit:927774] May, B, 2010-08-06
eventOf	[Pathway:R-HSA-975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) - Homo sapiens
followingEvent	[Reaction:R-HSA-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Homo sapiens
input	[Complex:R-HSA-927853] SMG1:SMG8:SMG9 Complex [cytosol] [Complex:R-HSA-927773] Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] [EntityWithAccessionedSequence:R-HSA-927734] UPF1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:927860] Y14 and hUpf3b form an NMD-activating complex [LiteratureReference:927779] NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity [LiteratureReference:927891] CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells [LiteratureReference:162434] The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay [LiteratureReference:927786] Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20 [LiteratureReference:927859] Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2 [LiteratureReference:927811] Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex [LiteratureReference:927791] The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay [LiteratureReference:927848] Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation [LiteratureReference:927740] Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay [LiteratureReference:927741] An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay [LiteratureReference:927795] eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay [LiteratureReference:927825] SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay [LiteratureReference:927758] Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways [LiteratureReference:927793] Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm [LiteratureReference:927877] Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1 [LiteratureReference:927810] Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements [LiteratureReference:1295716] UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps [LiteratureReference:1295712] An alternative branch of the nonsense-mediated decay pathway [LiteratureReference:1295709] A UPF3-mediated regulatory switch that maintains RNA surveillance [LiteratureReference:975936] Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors [LiteratureReference:975935] Execution of nonsense-mediated mRNA decay: what defines a substrate? [LiteratureReference:1295732] Gene expression networks: competing mRNA decay pathways in mammalian cells [LiteratureReference:1295735] The meaning of nonsense [LiteratureReference:975933] The nonsense-mediated decay RNA surveillance pathway [LiteratureReference:1295745] Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay [LiteratureReference:1295720] Recognition and elimination of nonsense mRNA [LiteratureReference:1295744] Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex
orthologousEvent	[Reaction:R-XTR-927832] UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex - Xenopus tropicalis [Reaction:R-DRE-927832] UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex - Danio rerio [Reaction:R-SSC-927832] UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex - Sus scrofa [Reaction:R-BTA-927832] UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex - Bos taurus [Reaction:R-CFA-927832] UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex - Canis familiaris [Reaction:R-RNO-927832] UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex - Rattus norvegicus [Reaction:R-MMU-927832] UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex - Mus musculus
output	[Complex:R-HSA-927767] SMG1:UPF1:EJC:Translated mRNP [cytosol]
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1296158] Neu-Yilik, G, 2011-05-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-927832
summation	[Summation:927872] The presence of an exon junction complex (EJC) downstream of...

Referrals

(hasEvent)	[Pathway:R-HSA-975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
(precedingEvent)	[Reaction:R-HSA-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)

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