Reactome | SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)

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SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) Show undefined attributes

authored	[InstanceEdit:927774] May, B, 2010-08-06
catalystActivity	[CatalystActivity:927781] protein serine/threonine kinase activity of SMG1:UPF1:EJC:Translated mRNP [cytosol]
catalystActivityReference	[CatalystActivityReference:9643452] protein kinase C activity of SMG1:UPF1:EJC:Translated mRNP [cytosol] Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:927892] May, B, 2010-08-10
dbId	927889
displayName	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)
edited	[InstanceEdit:927774] May, B, 2010-08-06
eventOf	[Pathway:R-HSA-975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-927813] p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-927767] SMG1:UPF1:EJC:Translated mRNP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:927740] Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay [LiteratureReference:927739] Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay [LiteratureReference:927825] SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay [LiteratureReference:1295742] Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein [LiteratureReference:927794] Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7 [LiteratureReference:1295729] Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex [LiteratureReference:975935] Execution of nonsense-mediated mRNA decay: what defines a substrate?
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)
orthologousEvent	[Reaction:R-PFA-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Plasmodium falciparum [Reaction:R-SCE-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Saccharomyces cerevisiae [Reaction:R-SPO-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Schizosaccharomyces pombe [Reaction:R-DDI-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Dictyostelium discoideum [Reaction:R-CEL-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Caenorhabditis elegans [Reaction:R-DME-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Drosophila melanogaster [Reaction:R-GGA-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Gallus gallus [Reaction:R-XTR-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Xenopus tropicalis [Reaction:R-DRE-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Danio rerio [Reaction:R-SSC-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Sus scrofa [Reaction:R-BTA-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Bos taurus [Reaction:R-CFA-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Canis familiaris [Reaction:R-RNO-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Rattus norvegicus [Reaction:R-MMU-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-927890] SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol]
precedingEvent	[Reaction:R-HSA-927832] UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1296158] Neu-Yilik, G, 2011-05-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-927889
summation	[Summation:927879] SMG1 phosphorylates UPF1 in vitro and in vivo (Denning et al...

Referrals

(hasEvent)	[Pathway:R-HSA-975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
(precedingEvent)	[BlackBoxEvent:R-HSA-927813] p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A

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