Reactome | Nonsense-Mediated Decay (NMD)

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Nonsense-Mediated Decay (NMD) Show undefined attributes

authored	[InstanceEdit:927774] May, B, 2010-08-06
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:927892] May, B, 2010-08-10
dbId	927802
displayName	Nonsense-Mediated Decay (NMD)
edited	[InstanceEdit:927774] May, B, 2010-08-06
eventOf	[TopLevelPathway:R-HSA-8953854] Metabolism of RNA - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:21780] nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) - Homo sapiens [Pathway:R-HSA-975956] Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-12-18
literatureReference	[LiteratureReference:975936] Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors [LiteratureReference:975935] Execution of nonsense-mediated mRNA decay: what defines a substrate? [LiteratureReference:975938] mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons [LiteratureReference:975933] The nonsense-mediated decay RNA surveillance pathway [LiteratureReference:975934] Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function [LiteratureReference:1295735] The meaning of nonsense [LiteratureReference:1295718] NMD: multitasking between mRNA surveillance and modulation of gene expression [LiteratureReference:1295734] NMD: RNA biology meets human genetic medicine [LiteratureReference:1295721] SnapShot: Nonsense-Mediated mRNA Decay
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Nonsense-Mediated Decay (NMD)
orthologousEvent	[Pathway:R-PFA-927802] Nonsense-Mediated Decay (NMD) - Plasmodium falciparum [Pathway:R-SCE-927802] Nonsense-Mediated Decay (NMD) - Saccharomyces cerevisiae [Pathway:R-SPO-927802] Nonsense-Mediated Decay (NMD) - Schizosaccharomyces pombe [Pathway:R-DDI-927802] Nonsense-Mediated Decay (NMD) - Dictyostelium discoideum [Pathway:R-CEL-927802] Nonsense-Mediated Decay (NMD) - Caenorhabditis elegans [Pathway:R-DME-927802] Nonsense-Mediated Decay (NMD) - Drosophila melanogaster [Pathway:R-GGA-927802] Nonsense-Mediated Decay (NMD) - Gallus gallus [Pathway:R-XTR-927802] Nonsense-Mediated Decay (NMD) - Xenopus tropicalis [Pathway:R-DRE-927802] Nonsense-Mediated Decay (NMD) - Danio rerio [Pathway:R-SSC-927802] Nonsense-Mediated Decay (NMD) - Sus scrofa [Pathway:R-BTA-927802] Nonsense-Mediated Decay (NMD) - Bos taurus [Pathway:R-CFA-927802] Nonsense-Mediated Decay (NMD) - Canis familiaris [Pathway:R-RNO-927802] Nonsense-Mediated Decay (NMD) - Rattus norvegicus [Pathway:R-MMU-927802] Nonsense-Mediated Decay (NMD) - Mus musculus
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1296158] Neu-Yilik, G, 2011-05-19
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-927802
summation	[Summation:927821] The Nonsense-Mediated Decay (NMD) pathway activates the dest...
updateTrackers	[UpdateTracker:9782724] Update Tracker - [Pathway:927802] Nonsense-Mediated Decay (NMD) - v58:[updateIndirectRLE] [UpdateTracker:9780202] Update Tracker - [Pathway:927802] Nonsense-Mediated Decay (NMD) - v63:[updateIndirectRLE]

Referrals

(updatedInstance)	[UpdateTracker:9782724] Update Tracker - [Pathway:927802] Nonsense-Mediated Decay (NMD) - v58:[updateIndirectRLE] [UpdateTracker:9780202] Update Tracker - [Pathway:927802] Nonsense-Mediated Decay (NMD) - v63:[updateIndirectRLE]
(hasEvent)	[TopLevelPathway:R-HSA-8953854] Metabolism of RNA
(hasEncapsulatedEvent)	[Pathway:R-HSA-376176] Signaling by ROBO receptors

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