Reactome | apoTF binds 2Fe3+ to form holoTF

apoTF binds 2Fe3+ to form holoTF

Stable Identifier

R-HSA-917888

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region

Synonyms

apo-Transferrin is loaded with two iron ions

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Transferrin (TF) is the main transporter of iron in the blood. The apo-form of TF can take up two ferric iron ions (Fe3+) to form holoTF (Wally et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16793765	The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding Mason, AB, Halbrooks, PJ, Wally, J, Everse, SJ, Vonrhein, C, Buchanan, SK, Rould, MA	J Biol Chem	2006