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apoTF binds 2Fe3+ to form holoTF
Stable Identifier
R-HSA-917888
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
apo-Transferrin is loaded with two iron ions
ReviewStatus
5/5
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Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
apoTF binds 2Fe3+ to form holoTF (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Transferrin (TF) is the main transporter of iron in the blood. The apo-form of TF can take up two ferric iron ions (Fe3+) to form holoTF (Wally et al. 2006).
Literature References
PubMed ID
Title
Journal
Year
16793765
The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding
Mason, AB
,
Halbrooks, PJ
,
Wally, J
,
Everse, SJ
,
Vonrhein, C
,
Buchanan, SK
,
Rould, MA
J Biol Chem
2006
Participants
Input
apoTF [extracellular region]
(Homo sapiens)
x 2
Fe3+ [extracellular region]
Output
holoTF [extracellular region]
(Homo sapiens)
Participates
as an event of
Iron uptake and transport (Homo sapiens)
Orthologous Events
apoTF binds 2Fe3+ to form holoTF (Bos taurus)
apoTF binds 2Fe3+ to form holoTF (Drosophila melanogaster)
apoTF binds 2Fe3+ to form holoTF (Gallus gallus)
apoTF binds 2Fe3+ to form holoTF (Mus musculus)
apoTF binds 2Fe3+ to form holoTF (Rattus norvegicus)
apoTF binds 2Fe3+ to form holoTF (Sus scrofa)
apoTF binds 2Fe3+ to form holoTF (Xenopus tropicalis)
Authored
Stephan, R (2010-07-07)
Reviewed
D'Eustachio, P (2010-11-05)
Created
Jassal, B (2010-07-30)
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