Reactome | Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2

Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2

Stable Identifier

R-HSA-913370

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2

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The alpha subunit of the IL5 receptor binds IL-5 with relatively low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of ligand with the alpha chain to form a binary complex. This binary complex may bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
2065657	Molecular basis of a high affinity murine interleukin-5 receptor Vandekerckhove, J, Fiers, W, Devos, R, Van der Heyden, J, Plaetinck, G, Tavernier, J, Cornelis, S	EMBO J	1991
1833065	A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF Fiers, W, Devos, R, Van der Heyden, J, Plaetinck, G, Tuypens, T, Tavernier, J, Cornelis, S	Cell	1991