Reactome | Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2

Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2

Stable Identifier

R-HSA-913370

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The alpha subunit of the IL5 receptor binds IL-5 with relatively low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of ligand with the alpha chain to form a binary complex. This binary complex may bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
2065657	Molecular basis of a high affinity murine interleukin-5 receptor Devos, R, Plaetinck, G, Van der Heyden, J, Cornelis, S, Vandekerckhove, J, Fiers, W, Tavernier, J	EMBO J	1991
1833065	A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF Tavernier, J, Devos, R, Cornelis, S, Tuypens, T, Van der Heyden, J, Fiers, W, Plaetinck, G	Cell	1991