Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The alpha subunit of the IL5 receptor binds IL-5 with relatively low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of ligand with the alpha chain to form a binary complex. This binary complex may bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008).

Literature References
PubMed ID Title Journal Year
1833065 A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF

Tavernier, J, Devos, R, Cornelis, S, Tuypens, T, Van der Heyden, J, Fiers, W, Plaetinck, G

Cell 1991
2065657 Molecular basis of a high affinity murine interleukin-5 receptor

Devos, R, Plaetinck, G, Van der Heyden, J, Cornelis, S, Vandekerckhove, J, Fiers, W, Tavernier, J

EMBO J 1991
Participant Of
Cite Us!