Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2

Stable Identifier
R-HSA-913370
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The alpha subunit of the IL5 receptor binds IL-5 with relatively low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of ligand with the alpha chain to form a binary complex. This binary complex may bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008).

Literature References
PubMed ID Title Journal Year
1833065 A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF

Tavernier, J, Devos, R, Cornelis, S, Tuypens, T, Van der Heyden, J, Fiers, W, Plaetinck, G

Cell 1991
2065657 Molecular basis of a high affinity murine interleukin-5 receptor

Devos, R, Plaetinck, G, Van der Heyden, J, Cornelis, S, Vandekerckhove, J, Fiers, W, Tavernier, J

EMBO J 1991
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