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Interleukin receptor SHC signaling
Stable Identifier
R-HSA-912526
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
General
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Phosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor complex. These phosphorylated tyrosines subsequently bind SH2 signaling proteins such as Grb2, Gab2 and SHIP that are involved in the regulation of different signaling pathways. Grb2 can associate with the guanosine diphosphate-guanosine triphosphate exchange factor Sos1, leading to Ras activation and regulation of cell proliferation. Downstream signals are mediated via the Raf-MEK-Erk pathway.Grb2 can also associate through Gab2 with PI3K and with SHIP.
Figure reproduced from Gu, H. et al. 2000. Mol. Cell. Biol. 20(19):7109-7120
Copyright American Society for Microbiology. All Rights Reserved.
Literature References
PubMed ID
Title
Journal
Year
8294403
The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation
Ravichandran, KS
,
Burakoff, SJ
J Biol Chem
1994
Participants
Events
Phosphorylated SHC1 recruits GRB2:GAB2
(Homo sapiens)
SHC1 mediates cytokine-induced phosphorylation of GAB2
(Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases
(Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1
(Homo sapiens)
Phosphorylated SHC1 recruits SHIP
(Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2
(Homo sapiens)
Participates
as an event of
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Orthologous Events
Interleukin receptor SHC signaling (Bos taurus)
Interleukin receptor SHC signaling (Canis familiaris)
Interleukin receptor SHC signaling (Gallus gallus)
Interleukin receptor SHC signaling (Mus musculus)
Interleukin receptor SHC signaling (Rattus norvegicus)
Interleukin receptor SHC signaling (Sus scrofa)
Cross References
BioModels Database
BIOMD0000000399
,
BIOMD0000000883
,
BIOMD0000000466
,
BIOMD0000000019
,
BIOMD0000000424
,
BIOMD0000001077
,
BIOMD0000000468
,
BIOMD0000000175
,
BIOMD0000000314
,
BIOMD0000000255
,
BIOMD0000000313
,
BIOMD0000000968
,
BIOMD0000000724
Authored
Ray, KP (2010-05-17)
Reviewed
Dooms, H (2011-03-17)
Villarino, A (2011-02-11)
Created
Jupe, S (2010-07-09)
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