Reactome | CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1

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CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 Show undefined attributes

catalystActivity	[CatalystActivity:9037765] monooxygenase activity of CYP1A1, CYP1A2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:9037754] Jassal, Bijay, 2018-02-21
dbId	9037761
displayName	CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1
eventOf	[Pathway:R-HSA-9018681] Biosynthesis of protectins - Homo sapiens
input	[SimpleEntity:R-ALL-9024886] (N)PD1 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9037760] Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1 [LiteratureReference:9037767] Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1
orthologousEvent	[Reaction:R-DRE-9037761] CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 - Danio rerio [Reaction:R-SSC-9037761] CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 - Sus scrofa [Reaction:R-BTA-9037761] CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 - Bos taurus [Reaction:R-RNO-9037761] CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 - Rattus norvegicus [Reaction:R-MMU-9037761] CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 - Mus musculus
output	[SimpleEntity:R-ALL-9037755] 22-OH-(N)PD1 [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-9024890] LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9037761
summation	[Summation:9037778] Protectin D1, identified as (N)PD1 (N signifies neuroprotect...

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(hasEvent)

[Pathway:R-HSA-9018681] Biosynthesis of protectins

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