Reactome | CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1

CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1

Stable Identifier

R-HSA-9037761

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1

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Protectin D1, identified as (N)PD1 (N signifies neuroprotectin when produced in neural tissues), is a natural product derived from docosahexaenoic acid (DHA) through the actions of 15 lipoxygenase followed by enzymatic hydrolysis by an unidentified hydrolase. (N)PD1 is one of the specialized proresolving mediators (SPMs) that show potent anti inflammatory and pro resolving actions (Molfino et al. 2017, Balas & Durand 2016). (N)PD1 has been the subject of many pharmacological studies for the development of potential new anti inflammatory drugs. The 22 hydroxylated metabolite of (N)PD1 (here signified as 22 OH (N)PD1) has been shown to exhibit potent pro resolving actions by inhibiting PMN chemotaxis in vivo with mice and in vitro with human cells and decreases pro inflammatory mediator levels in inflammatory exudates. These observations were comparable to those of its precursor (N)PD1 (Tungen et al. 2014). 22 OH (N)PD1 is most likely formed by the action of CYP1 monooxygenases, just like for some other SPMs (Divanovic et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23956430	Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways Divanovic, S, Dalli, J, Jorge-Nebert, LF, Flick, LM, Gálvez-Peralta, M, Boespflug, ND, Stankiewicz, TE, Fitzgerald, JM, Somarathna, M, Karp, CL, Serhan, CN, Nebert, DW	J. Immunol.	2013
25247845	Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1 Tungen, JE, Aursnes, M, Vik, A, Ramon, S, Colas, RA, Dalli, J, Serhan, CN, Hansen, TV	J. Nat. Prod.	2014