Reactome | MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane]

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MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[FailedReaction:R-HSA-5602383] Defective MyD88 does not oligomerize within the activated TLR2/4 complex - Homo sapiens
created	[InstanceEdit:9037686] Shamovsky, Veronica, 2018-02-20
crossReference	[DatabaseIdentifier:12021025] Mondo:0003778
dbId	9037685
disease	[Disease:5228860] primary immunodeficiency disease
displayName	MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane]
hasComponent	[Complex:R-HSA-2201325] activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] 2 × [CandidateSet:R-HSA-5602754] MyD88 variants [cytosol]
inDisease	true
includedLocation	[Compartment:70101] cytosol
maxDepth	8
modified	[InstanceEdit:9658481] Shamovsky, Veronica, 2019-08-14
name	MyD88 variant:TIRAP:BTK:activated TLR2/4 MyD88 variant:MAL:BTK:activated TLR2/4
relatedSpecies	[Species:181384] Chlamydia trachomatis [Species:180800] Neisseria meningitidis serogroup B
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9037685
updateTrackers	[UpdateTracker:9899669] Update Tracker - [Complex:9037685] MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v67:[updateContainedComponent] [UpdateTracker:9899475] Update Tracker - [Complex:9037685] MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v66:[addName, updateContainedComponent] [UpdateTracker:9900837] Update Tracker - [Complex:9037685] MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v70:[addDisease] [UpdateTracker:9902094] Update Tracker - [Complex:9037685] MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v76:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9899669] Update Tracker - [Complex:9037685] MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v67:[updateContainedComponent] [UpdateTracker:9899475] Update Tracker - [Complex:9037685] MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v66:[addName, updateContainedComponent] [UpdateTracker:9900837] Update Tracker - [Complex:9037685] MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v70:[addDisease] [UpdateTracker:9902094] Update Tracker - [Complex:9037685] MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v76:[updateContainedComponent]
(input)	[FailedReaction:R-HSA-5602383] Defective MyD88 does not oligomerize within the activated TLR2/4 complex
(diseaseEntity)	[EntityFunctionalStatus:9658483] loss_of_function of MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane]

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