FUT2 transfers Fuc to Type 1 chains to form H antigen-sec

Stable Identifier
R-HSA-9036987
Type
Reaction [transition]
Species
Homo sapiens
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The H antigen is formed by the addition of a fucose (Fuc) sugar onto one of two precursor oligosaccharide sequences; Type 1 or Type 2 chains. Type 2 chains are found on red blood cells (RBCs), epithelial cells and endothelial cells whereas Type 1 chains are primarily found in bodily secretions. The FUT2 gene (aka Se gene) is expressed in secretory epithelial cells in salivary glands and the gastrointestinal tract and produces galactoside 2-α-L-fucosyltransferase 2 (FUT2 aka α-1,2-fucosyltransferase 2) which mediates the transfer of a Fuc sugar to the galactose (Gal) sugar of the Type 1 chain precursor Gal-β1,3-GlcNAc-β1,3-Gal-R (where R is a glycoprotein) to form the H antigen (Kelly et al. 1995, Koda et al. 1997). This is an essential step for subsequent formation of A and B antigens. Mutations that inactivate the FUT2 gene can result in the 'Bombay phenotype' where no A, B or H antigens are produced in secretions (Koda et al 1997b, Kelly et al. 1994).

Literature References
PubMed ID Title Journal Year
9219535 Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2)

Koda, Y, Soejima, M, Wang, B, Kimura, H

Eur. J. Biochem. 1997
7876235 Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype

Kelly, RJ, Rouquier, S, Giorgi, D, Lennon, GG, Lowe, JB

J. Biol. Chem. 1995
9299444 Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system

Koda, Y, Soejima, M, Johnson, PH, Smart, E, Kimura, H

Biochem. Biophys. Res. Commun. 1997
7912436 Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals

Kelly, RJ, Ernst, LK, Larsen, RD, Bryant, JG, Robinson, JS, Lowe, JB

Proc. Natl. Acad. Sci. U.S.A. 1994
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Catalyst Activity
Title
galactoside 2-alpha-L-fucosyltransferase activity of FUT2 [Golgi membrane]
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Orthologous Events
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