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Schema
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FailedReaction
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Entries
Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)5 (PP-Dol)1 by ALG3
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authored
[InstanceEdit:4686999] Jassal, B, 2013-10-15
category
transition
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:453088] integral component of lumenal side of endoplasmic reticulum membrane
created
[InstanceEdit:4686999] Jassal, B, 2013-10-15
dbId
9036025
disease
[Disease:3781892] congenital disorder of glycosylation type I
displayName
Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)5 (PP-Dol)1 by ALG3
edited
[InstanceEdit:4686999] Jassal, B, 2013-10-15
entityFunctionalStatus
[EntityFunctionalStatus:4717402] loss_of_function of MPDU1 mutants [endoplasmic reticulum membrane]
eventOf
[Pathway:R-HSA-4687000] Defective MPDU1 causes CDG-1f - Homo sapiens
input
[SimpleEntity:R-ALL-449298] (GlcNAc)2 (Man)5 (PP-Dol)1 [integral component of lumenal side of endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-449229] DOLP-Man [integral component of lumenal side of endoplasmic reticulum membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:4717386] MPDU1 mutations underlie a novel human congenital disorder of glycosylation, designated type If
[LiteratureReference:4717421] Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals
[LiteratureReference:4717369] A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If)
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)5 (PP-Dol)1 by ALG3
normalReaction
[Reaction:R-HSA-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1
regulatedBy
[PositiveRegulation:9631953] Positive regulation by 'MPDU1 mutants [endoplasmic reticulum membrane]'
releaseDate
2014-12-11
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5633220] Belaya, Katsiaryna, 2014-10-31
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9036025
summation
[Summation:9036022] Mannose-P-dolichol utilisation defect 1 protein (MPDU1) is r...
systematicName
MPDU1 mutants do not transfer Man from DOLPman to ALG substrates
Referrals
(hasEvent)
[Pathway:R-HSA-4687000] Defective MPDU1 causes CDG-1f
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