Reactome | ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1

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ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 Show undefined attributes

authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:449317] alpha-1,3-mannosyltransferase activity of ALG3 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:446206] Jassal, B, 2009-11-10
dbId	446188
displayName	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1
edited	[InstanceEdit:446206] Jassal, B, 2009-11-10
eventOf	[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Homo sapiens
figure	[Figure:975562] /figures/9_GlcNAc2Man6PPDol.png
followingEvent	[Reaction:R-HSA-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Homo sapiens
input	[SimpleEntity:R-ALL-449298] (GlcNAc)2 (Man)5 (PP-Dol)1 [integral component of lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-449229] DOLP-Man [integral component of lumenal side of endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:449316] Congenital disorder of glycosylation id presenting with hyperinsulinemic hypoglycemia and islet cell hyperplasia [LiteratureReference:449896] Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 Addition of the sixth mannose to the N-glycan precursor by ALG3
orthologousEvent	[Reaction:R-SCE-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Saccharomyces cerevisiae [Reaction:R-SPO-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Schizosaccharomyces pombe [Reaction:R-DDI-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Dictyostelium discoideum [Reaction:R-CEL-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Caenorhabditis elegans [Reaction:R-DME-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Drosophila melanogaster [Reaction:R-GGA-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Gallus gallus [Reaction:R-XTR-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Xenopus tropicalis [Reaction:R-DRE-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Danio rerio [Reaction:R-SSC-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Sus scrofa [Reaction:R-BTA-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Bos taurus [Reaction:R-CFA-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Canis familiaris [Reaction:R-RNO-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Rattus norvegicus [Reaction:R-MMU-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Mus musculus
output	[SimpleEntity:R-ALL-449315] (GlcNAc)2 (Man)6 (PP-Dol)1 [integral component of lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-449311] DOLP [integral component of lumenal side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-446212] Flipping of the N-glycan precursor to inside the ER - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-4628424] Positive regulation by 'MPDU1 [endoplasmic reticulum membrane]'
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:749519] Gagneux, P, 2010-04-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-446188
summation	[Summation:449261] The sixth mannose is added to the N-glycan precursor. This r...

Referrals

(normalReaction)	[FailedReaction:R-HSA-9036025] Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)5 (PP-Dol)1 by ALG3 [FailedReaction:R-HSA-4720473] Defective ALG3 does not add mannose to the N-glycan precursor
(hasEvent)	[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
(precedingEvent)	[Reaction:R-HSA-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1

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