As well as being a Golgi membrane resident, the histo-blood group ABO system transferase (ABO) can be proteolytically processed by an unknown protease into a soluble form, fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase (sABO). A, B and AB individuals express glycosyltransferase activities that convert the H antigen to the A antigen (by addition of GalNAc), to the B antigen (by addition of Gal) or to the AB antigen (by the addition of both GalNAc and Gal). O group individuals lack such activity. Differences in four critical amino acids (176, 235, 266 and 268) alter the specificity from an A to a B glycosyltransferase (Yamamoto et al. 1990, Yamamoto & McNeill 1996, Seto et al. 1999, Alfaro et al. 2008). The soluble form of histo-blood group A transferase (sABO-A) utilises UDP-GalNAc to transfer N-acetylgalactosamine (GalNAc) to the H antigen formed via Type 1 chains to form the A antigen in secretors (A antigen-sec) (Patenaude et al. 2002, Persson et al. 2007).
Marken, J, White, T, Yamamoto, F, Hakomori, S, Clausen, H
Seto, NO, Bai, Y, Borisova, SN, Persson, M, Alfaro, JA, Evans, SV, Polakowski, R, Letts, JA, Zheng, RB, Palcic, MM, Lowary, TL
Yamamoto, F, McNeill, PD
Marcus, SL, Seto, NO, Borisova, SN, Evans, SV, Patenaude, SI, Szpacenko, A, Palcic, MM
Evans, SV, Bundle, DR, Palcic, MM, Compston, CA, Seto, NO, Narang, SA
Hosseini-Maaf, B, Borisova, SN, Persson, M, Olsson, ML, Evans, SV, Letts, JA, Palcic, MM
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity of sABO-A:Mn2+ [extracellular region]
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