NTF3 activates NTRK3 signaling

Stable Identifier
Homo sapiens
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NTRK3 (TRKC) is activated by binding to its ligand neurotrophin-3 (NTF3, also known as NT-3). Ligand binding induces dimerization of NTRK3 and trans-autophosphorylation of dimerized receptors on conserved tyrosine residues in the cytoplasmic tail. Autophosphorylated tyrosines serve as docking sites for binding of adaptor proteins that mediate downstream signaling (Lamballe et al. 1991, Philo et al. 1994, Tsoulfas et al. 1996, Huang and Reichardt 2001, Werner et al. 2014).

Literature References
PubMed ID Title Journal Year
8621434 TrkC isoforms with inserts in the kinase domain show impaired signaling responses

Parada, LF, Stephens, RM, Tsoulfas, P, Kaplan, DR

J. Biol. Chem. 1996
1653651 trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

Barbacid, M, Klein, R, Lamballe, F

Cell 1991
7961713 Interactions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and the NT-3.BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors

Rosenfeld, R, Wen, J, Philo, J, Welcher, A, Arakawa, T, Talvenheimo, J

J. Biol. Chem. 1994
11520916 Neurotrophins: roles in neuronal development and function

Reichardt, LF, Huang, EJ

Annu. Rev. Neurosci. 2001
25196463 Mutations in NTRK3 suggest a novel signaling pathway in human congenital heart disease

Iyer, R, Goldmuntz, E, Simpson, AM, Brodeur, GM, Latney, B, Werner, P, Paluru, P

Hum. Mutat. 2014
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