Reactome | NTF3 activates NTRK3 signaling

NTF3 activates NTRK3 signaling

Stable Identifier

R-HSA-9034013

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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NTRK3 (TRKC) is activated by binding to its ligand neurotrophin-3 (NTF3, also known as NT-3). Ligand binding induces dimerization of NTRK3 and trans-autophosphorylation of dimerized receptors on conserved tyrosine residues in the cytoplasmic tail. Autophosphorylated tyrosines serve as docking sites for binding of adaptor proteins that mediate downstream signaling (Lamballe et al. 1991, Philo et al. 1994, Tsoulfas et al. 1996, Huang and Reichardt 2001, Werner et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
8621434	TrkC isoforms with inserts in the kinase domain show impaired signaling responses Parada, LF, Stephens, RM, Tsoulfas, P, Kaplan, DR	J. Biol. Chem.	1996
1653651	trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3 Barbacid, M, Klein, R, Lamballe, F	Cell	1991
7961713	Interactions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and the NT-3.BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors Rosenfeld, R, Wen, J, Philo, J, Welcher, A, Arakawa, T, Talvenheimo, J	J. Biol. Chem.	1994
11520916	Neurotrophins: roles in neuronal development and function Reichardt, LF, Huang, EJ	Annu. Rev. Neurosci.	2001
25196463	Mutations in NTRK3 suggest a novel signaling pathway in human congenital heart disease Iyer, R, Goldmuntz, E, Simpson, AM, Brodeur, GM, Latney, B, Werner, P, Paluru, P	Hum. Mutat.	2014