NTRK3 (TRKC) is activated by binding to its ligand neurotrophin-3 (NTF3, also known as NT-3). Ligand binding induces dimerization of NTRK3 and trans-autophosphorylation of dimerized receptors on conserved tyrosine residues in the cytoplasmic tail. Autophosphorylated tyrosines serve as docking sites for binding of adaptor proteins that mediate downstream signaling (Lamballe et al. 1991, Philo et al. 1994, Tsoulfas et al. 1996, Huang and Reichardt 2001, Werner et al. 2014).