DOCK3 activates RAC1 and contributes to recruitment of the RAC1 effector WASF1 (WAVE1). DOCK3-mediated activation of RAC1 is involved in BDNF-induced axonal sprouting (Namekata et al. 2010).
WASF1 has recently been implicated in endocytosis of the BDNF:NTRK2 (BDNF:TRKB) complex (Xu et al. 2016).
Namekata, K, Harada, C, Taya, C, Guo, X, Kimura, H, Parada, LF, Harada, T
guanyl-nucleotide exchange factor activity of BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:DOCK3 [plasma membrane]
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