Phosphorylated SHC1 in the EPOR complex serves as a scaffold to bind GRB2 bound to SOS1 (Damen et al. 1993, Odai et al. 1997). GRB2 may be pre-associated with VAV1 or SOS1, which are guanine nucleotide exchange factors for RAS, or with CBL, an ubiquitin ligase (Odai et al. 1997).
Cutler, RL, Liu, L, Krystal, G, Damen, JE
Yazaki, Y, Hanazono, Y, Odai, H, Iwamatu, A, Hirai, H, Sasaki, K
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