Reactome | ALOX5 oxidises DPAn-3 to 7-HDPAn-3

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ALOX5 oxidises DPAn-3 to 7-HDPAn-3 Show undefined attributes

authored	[InstanceEdit:9027630] Jassal, Bijay, 2017-11-03
catalystActivity	[CatalystActivity:9020578] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9027630] Jassal, Bijay, 2017-11-03
dbId	9027633
displayName	ALOX5 oxidises DPAn-3 to 7-HDPAn-3
edited	[InstanceEdit:9027630] Jassal, Bijay, 2017-11-03
eventOf	[Pathway:R-HSA-9027604] Biosynthesis of electrophilic ?-3 PUFA oxo-derivatives - Homo sapiens
followingEvent	[Reaction:R-HSA-9027625] 5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3 - Homo sapiens
input	[SimpleEntity:R-ALL-9608444] DPAn-3 [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9028212] Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ALOX5 oxidises DPAn-3 to 7-HDPAn-3
orthologousEvent	[Reaction:R-DDI-9027633] ALOX5 oxidises DPAn-3 to 7-HDPAn-3 - Dictyostelium discoideum [Reaction:R-GGA-9027633] ALOX5 oxidises DPAn-3 to 7-HDPAn-3 - Gallus gallus [Reaction:R-XTR-9027633] ALOX5 oxidises DPAn-3 to 7-HDPAn-3 - Xenopus tropicalis [Reaction:R-DRE-9027633] ALOX5 oxidises DPAn-3 to 7-HDPAn-3 - Danio rerio [Reaction:R-SSC-9027633] ALOX5 oxidises DPAn-3 to 7-HDPAn-3 - Sus scrofa [Reaction:R-BTA-9027633] ALOX5 oxidises DPAn-3 to 7-HDPAn-3 - Bos taurus [Reaction:R-CFA-9027633] ALOX5 oxidises DPAn-3 to 7-HDPAn-3 - Canis familiaris [Reaction:R-RNO-9027633] ALOX5 oxidises DPAn-3 to 7-HDPAn-3 - Rattus norvegicus [Reaction:R-MMU-9027633] ALOX5 oxidises DPAn-3 to 7-HDPAn-3 - Mus musculus
output	[SimpleEntity:R-ALL-9028240] 7-HDPAn-3 [cytosol]
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9027633
summation	[Summation:9028216] In human neutrophils, 5-lipoxygenase (ALOX5) can mediate the...
updateTrackers	[UpdateTracker:9779609] Update Tracker - [Reaction:9027633] ALOX5 oxidises DPAn-3 to 7-HDPAn-3 - v65:[add_removeInput]

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(updatedInstance)	[UpdateTracker:9779609] Update Tracker - [Reaction:9027633] ALOX5 oxidises DPAn-3 to 7-HDPAn-3 - v65:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-9027604] Biosynthesis of electrophilic ?-3 PUFA oxo-derivatives
(precedingEvent)	[Reaction:R-HSA-9027625] 5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3