In human neutrophils, 5-lipoxygenase (ALOX5) can mediate the...

created [InstanceEdit:9028211] Jassal, Bijay, 2017-11-07
dbId 9028216
displayName In human neutrophils, 5-lipoxygenase (ALOX5) can mediate the...
schemaClass Summation
text In human neutrophils, 5-lipoxygenase (ALOX5) can mediate the lipoxygenation of ?-3 docosapentaenoic acid (DPAn-3) to 7-hydroxy-?-3-docosapentaenoic acid (7-HDPAn-3) (Cipollina et al. 2014). Neutrophils treated with an ALOX5 inhibitor completely suppressed the formation of 7-oxo-DPAn-3 and its hydroxy precursor 7-HDPAn-3, demonstrating that ALOX5 mediates the first step in 7-oxo-DPAn-3 biosynthesis (Cipollina et al. 2014).
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