ALOX5 oxidises DPAn-3 to 7-HDPAn-3

Stable Identifier
R-HSA-9027633
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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In human neutrophils, 5-lipoxygenase (ALOX5) can mediate the lipoxygenation of ω-3 docosapentaenoic acid (DPAn-3) to 7-hydroxy-ω-3-docosapentaenoic acid (7-HDPAn-3) (Cipollina et al. 2014). Neutrophils treated with an ALOX5 inhibitor completely suppressed the formation of 7-oxo-DPAn-3 and its hydroxy precursor 7-HDPAn-3, demonstrating that ALOX5 mediates the first step in 7-oxo-DPAn-3 biosynthesis (Cipollina et al. 2014).
Literature References
PubMed ID Title Journal Year
24736647 Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives

Cipollina, C, Schopfer, FJ, Freeman, BA, Muldoon, MF, Salvatore, SR

PLoS ONE 2014
Participants
Participates
Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]

Orthologous Events
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