ALOX5 oxidises DPAn-3 to 7-HDPAn-3

Stable Identifier
R-HSA-9027633
Type
Reaction [transition]
Species
Homo sapiens
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In human neutrophils, 5-lipoxygenase (ALOX5) can mediate the lipoxygenation of ω-3 docosapentaenoic acid (DPAn-3) to 7-hydroxy-ω-3-docosapentaenoic acid (7-HDPAn-3) (Cipollina et al. 2014). Neutrophils treated with an ALOX5 inhibitor completely suppressed the formation of 7-oxo-DPAn-3 and its hydroxy precursor 7-HDPAn-3, demonstrating that ALOX5 mediates the first step in 7-oxo-DPAn-3 biosynthesis (Cipollina et al. 2014).

Literature References
PubMed ID Title Journal Year
24736647 Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives

Cipollina, C, Salvatore, SR, Muldoon, MF, Freeman, BA, Schopfer, FJ

PLoS ONE 2014
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Catalyst Activity

arachidonate 5-lipoxygenase activity of ALOX5 [cytosol]

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