ALOX5 oxidises DPAn-3 to 7-HDPAn-3

Stable Identifier
R-HSA-9027633
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ALOX5 oxidises DPAn-3 to 7-HDPAn-3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In human neutrophils, 5-lipoxygenase (ALOX5) can mediate the lipoxygenation of ω-3 docosapentaenoic acid (DPAn-3) to 7-hydroxy-ω-3-docosapentaenoic acid (7-HDPAn-3) (Cipollina et al. 2014). Neutrophils treated with an ALOX5 inhibitor completely suppressed the formation of 7-oxo-DPAn-3 and its hydroxy precursor 7-HDPAn-3, demonstrating that ALOX5 mediates the first step in 7-oxo-DPAn-3 biosynthesis (Cipollina et al. 2014).

Literature References
PubMed ID Title Journal Year
24736647 Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives

Cipollina, C, Schopfer, FJ, Freeman, BA, Muldoon, MF, Salvatore, SR

PLoS ONE 2014
Participants
Input
Output
Participates
as an event of
Catalyst Activity

arachidonate 5-lipoxygenase activity of ALOX5 [cytosol]

Physical Entity
ALOX5 [cytosol] (Homo sapiens)
Activity
arachidonate 5-lipoxygenase activity (GO:0004051)
Orthologous Events
ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Bos taurus)
ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Canis familiaris)
ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Danio rerio)
ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Dictyostelium discoideum)
ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Gallus gallus)
ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Mus musculus)
ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Rattus norvegicus)
ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Sus scrofa)
ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Xenopus tropicalis)
Authored
Jassal, B  (2017-11-03)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-11-03)
Cite Us!