Reactome | EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K

Schema > Reaction > Entries

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K Show undefined attributes

authored	[InstanceEdit:9027271] May, Bruce, 2017-10-29
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9027279] May, Bruce, 2017-10-29
dbId	9027280
displayName	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
edited	[InstanceEdit:9027271] May, Bruce, 2017-10-29
eventOf	[Pathway:R-HSA-9027276] Erythropoietin activates Phosphoinositide-3-kinase (PI3K) - Homo sapiens
followingEvent	[Reaction:R-HSA-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9027268] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k - Mus musculus
input	[Complex:R-HSA-9006301] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] [DefinedSet:R-HSA-9012640] PI3K alpha, gamma [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9027107] Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation [LiteratureReference:9012635] Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
output	[Complex:R-HSA-9027263] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane]
precedingEvent	[Reaction:R-HSA-9006323] Phospho-JAK2 phosphorylates EPOR - Homo sapiens
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9616793] McGraw, Kathy L, 2018-08-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9027280
summation	[Summation:9030314] Phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) can di...

Referrals

(hasEvent)	[Pathway:R-HSA-9027276] Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
(precedingEvent)	[Reaction:R-HSA-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3
(inferredTo)	[Reaction:R-MMU-9027268] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k

Cite Us!