EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K

Stable Identifier
R-HSA-9027280
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
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EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
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Phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) can directly bind phosphotyrosine-479 in the cytosolic domain of EPOR (Kubota et al. 2001, Bouscary et al. 2003, and inferred from mouse homologs).

Literature References
PubMed ID Title Journal Year
11598010 Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase

Kubota, Y, Tanaka, T, Kitanaka, A, Ohnishi, H, Okutani, Y, Waki, M, Ishida, T, Kamano, H

EMBO J. 2001
12506011 Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation

Bouscary, D, Pene, F, Claessens, YE, Muller, O, Chrétien, S, Fontenay-Roupie, M, Gisselbrecht, S, Mayeux, P, Lacombe, C

Blood 2003
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k (Mus musculus)
Authored
May, B  (2017-10-29)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-10-29)