Reactome | CYPs hydroxylate DHA to 14(R)-HDHA

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CYPs hydroxylate DHA to 14(R)-HDHA Show undefined attributes

authored	[InstanceEdit:9027051] Jassal, Bijay, 2017-10-27
catalystActivity	[CatalystActivity:9027048] monooxygenase activity of CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9027051] Jassal, Bijay, 2017-10-27
dbId	9027043
displayName	CYPs hydroxylate DHA to 14(R)-HDHA
edited	[InstanceEdit:9027051] Jassal, Bijay, 2017-10-27
eventOf	[Pathway:R-HSA-9027307] Biosynthesis of maresin-like SPMs - Homo sapiens
followingEvent	[Reaction:R-HSA-9027044] CYP4 ?-oxidises 14(R)-HDHA to MaR-L2 - Homo sapiens [Reaction:R-HSA-9027321] CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA - Homo sapiens
input	[SimpleEntity:R-ALL-9024011] DHA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9027018] Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	CYPs hydroxylate DHA to 14(R)-HDHA
orthologousEvent	[Reaction:R-DDI-9027043] CYPs hydroxylate DHA to 14(R)-HDHA - Dictyostelium discoideum [Reaction:R-CEL-9027043] CYPs hydroxylate DHA to 14(R)-HDHA - Caenorhabditis elegans [Reaction:R-GGA-9027043] CYPs hydroxylate DHA to 14(R)-HDHA - Gallus gallus [Reaction:R-XTR-9027043] CYPs hydroxylate DHA to 14(R)-HDHA - Xenopus tropicalis [Reaction:R-DRE-9027043] CYPs hydroxylate DHA to 14(R)-HDHA - Danio rerio [Reaction:R-SSC-9027043] CYPs hydroxylate DHA to 14(R)-HDHA - Sus scrofa [Reaction:R-BTA-9027043] CYPs hydroxylate DHA to 14(R)-HDHA - Bos taurus [Reaction:R-CFA-9027043] CYPs hydroxylate DHA to 14(R)-HDHA - Canis familiaris [Reaction:R-RNO-9027043] CYPs hydroxylate DHA to 14(R)-HDHA - Rattus norvegicus [Reaction:R-MMU-9027043] CYPs hydroxylate DHA to 14(R)-HDHA - Mus musculus
output	[SimpleEntity:R-ALL-9027049] 14(R)-HDHA [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9027043
summation	[Summation:9027050] Using human leukocytes and platelets, Hong et al. found that...

Referrals

(hasEvent)	[Pathway:R-HSA-9027307] Biosynthesis of maresin-like SPMs
(precedingEvent)	[Reaction:R-HSA-9027044] CYP4 ?-oxidises 14(R)-HDHA to MaR-L2 [Reaction:R-HSA-9027321] CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA