Reactome | CYPs hydroxylate DHA to 14(R)-HDHA

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CYPs hydroxylate DHA to 14(R)-HDHA Show undefined attributes

catalystActivity	[CatalystActivity:10544508] monooxygenase activity of CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10544510
displayName	CYPs hydroxylate DHA to 14(R)-HDHA
eventOf	[Pathway:R-SSC-9027307] Biosynthesis of maresin-like SPMs - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9027321] CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA - Sus scrofa
inferredFrom	[Reaction:R-HSA-9027043] CYPs hydroxylate DHA to 14(R)-HDHA - Homo sapiens
input	[SimpleEntity:R-ALL-9024011] DHA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYPs hydroxylate DHA to 14(R)-HDHA
output	[SimpleEntity:R-ALL-9027049] 14(R)-HDHA [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9027043
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9027307] Biosynthesis of maresin-like SPMs
(precedingEvent)	[Reaction:R-SSC-9027321] CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA
(inferredTo)	[Reaction:R-HSA-9027043] CYPs hydroxylate DHA to 14(R)-HDHA