BDNF activates NTRK2 (TRKB) signaling

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Homo sapiens
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Signaling by the neurotrophin receptor tyrosine kinase NTRK2 (TRKB) can be activated by binding to brain-derived neurotrophic factor (BDNF), which functions as a ligand for NTRK2 (Soppet et al. 1991, Klein et al. 1991). Binding to BDNF triggers NTRK2 dimerization (Ohira et al. 2001) and trans-autophosphorylation of NTRK2 dimers on conserved tyrosine residues in the cytoplasmic tail of the receptor (Guiton et al. 1994, Minichiello et al. 1998, McCarty and Feinstein 1999). Phosphorylated tyrosine residues subsequently serve as docking sites for recruitment of effector proteins that trigger downstream signaling cascades.

Literature References
PubMed ID Title Journal Year
9728915 Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses

Stucky, CL, Casagranda, F, Postigo, A, Tatche, RS, Klein, R, Davies, AM, Lewin, GR, Minichiello, L

Neuron 1998
10533983 The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL

Feinstein, SC, McCarty, JH

J. Recept. Signal Transduct. Res. 1999
11536331 TrkB dimerization during development of the prefrontal cortex of the macaque

Hayashi, M, Ohira, K, Shimizu, K

J. Neurosci. Res. 2001
1645620 The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

Parada, LF, Middlemas, DS, Maragos, J, Soppet, D, Escandon, E, Burton, LE, Hunter, T, Stanton, BR, Nikolics, K, Blair, J, Kaplan, DR, Reid, SW

Cell 1991
1649702 The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

Bryant, S, Jones, KR, Reichardt, LF, Barbacid, M, Jing, SA, Klein, R, Lamballe, F, Cordon-Cardo, C, Tapley, P, Nanduri, V

Cell 1991
7982951 Identification of in vivo brain-derived neurotrophic factor-stimulated autophosphorylation sites on the TrkB receptor tyrosine kinase by site-directed mutagenesis

Stitt, TN, Yancopoulos, GD, Guiton, M, Gunn-Moore, FJ, Tavaré, JM

J. Biol. Chem. 1994
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