DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)

Stable Identifier
R-HSA-9023632
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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Dipeptidyl Peptidase IV (DPP4) cleaves 2 amino acids from the N-terminus of GLP-1, inactivating it. DPP4 determines the half life of GLP-1 in the bloodstream. It is unknown if the soluble form of DPP4, the membrane-bound form, or both catalyze the cleavage of GLP-1.
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of DPP4(39-766) [extracellular region]

Orthologous Events
Authored
Reviewed
Created
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