Reactome | DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)

DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)

Stable Identifier

R-HSA-9023632

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)

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Dipeptidyl Peptidase IV (DPP4) cleaves 2 amino acids from the N-terminus of GLP-1, inactivating it. DPP4 determines the half life of GLP-1 in the bloodstream. It is unknown if the soluble form of DPP4, the membrane-bound form, or both catalyze the cleavage of GLP-1.

Literature References

PubMed ID	Title	Journal	Year
14719797	Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme Bar, J, Weber, A, Hoffmann, T, Stork, J, Wermann, M, Wagner, L, Aust, S, Gerhartz, B, Demuth, HU	Biol Chem	2003
7883856	Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo Deacon, CF, Johnsen, AH, Holst, JJ	J Clin Endocrinol Metab	1995
15584901	Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders Gorrell, MD	Clin Sci (Lond)	2005
8798518	Investigation of glucose-dependent insulinotropic polypeptide-(1-42) and glucagon-like peptide-1-(7-36) degradation in vitro by dipeptidyl peptidase IV using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. A novel kinetic approach Pauly, RP, Rosche, F, Wermann, M, McIntosh, CH, Pederson, RA, Demuth, HU	J Biol Chem	1996
8100523	Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum Mentlein, R, Gallwitz, B, Schmidt, WE	Eur J Biochem	1993