Reactome | MECP2 T158A:SIN3A complex does not bind BDNF gene promoter

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MECP2 T158A:SIN3A complex does not bind BDNF gene promoter Show undefined attributes

authored	[InstanceEdit:9024208] Orlic-Milacic, Marija, 2017-10-02
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9023460] Orlic-Milacic, Marija, 2017-09-27
crossReference	[DatabaseIdentifier:12020964] Mondo:0010726
dbId	9023461
disease	[Disease:9005548] Rett syndrome
displayName	MECP2 T158A:SIN3A complex does not bind BDNF gene promoter
edited	[InstanceEdit:9615799] Orlic-Milacic, Marija, 2018-08-08
entityFunctionalStatus	[EntityFunctionalStatus:9023462] loss_of_function of MECP2 T158A:SIN3A:HDAC1 [nucleoplasm]
eventOf	[Pathway:R-HSA-9022538] Loss of MECP2 binding ability to 5mC-DNA - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9006123] BDNF gene [nucleoplasm] [Complex:R-HSA-9023459] MECP2 T158A:SIN3A:HDAC1 [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9023429] Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MECP2 T158A:SIN3A complex does not bind BDNF gene promoter
normalReaction	[Reaction:R-HSA-9006050] MECP2:SIN3A complex binds the promoter of the BDNF gene
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608119] Krishnaraj, Rahul, 2018-08-07 [InstanceEdit:9608114] Christodoulou, John, 2018-08-07
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9023461
summation	[Summation:9023463] The Rett syndrome-causing MECP2 T158A mutant is unable to bi...

Referrals

(hasEvent)

[Pathway:R-HSA-9022538] Loss of MECP2 binding ability to 5mC-DNA

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